Heaslip links up in the back row with new inclusions Dominic Ryan and Shane Jennings, with Kevin McLaughlin switching to second row alongside Devin Toner.
Jack McGrath will make his sixth Magners League appearance in the front row alongside Richardt Strauss and Stan Wright.
Gordon D'Arcy lines up at centre alongside Eoin O'Malley, who has featured in 19 games so far this season. Fergus McFadden, meanwhile, is set to bring up his half century of caps in Leinster colours on the left wing.
Cian Healy is one of four international forwards on the province's replacements bench alongside Nathan Hines, Mike Ross and Rhys Ruddock.
There will be a specially themed bumper 'Kids Takeover Day' at the RDS this Friday evening.
Great value family tickets are available now for only €50 for two adults and two children here and tickets are available from Ticketmaster outlets nationwide and will be on sale around the ground on the night.
LEINSTER (v Glasgow Warriors): Isa Nacewa; Shane Horgan, Eoin O'Malley, Gordon D'Arcy, Fergus McFadden; Ian Madigan, Isaac Boss; Jack McGrath, Richardt Strauss, Stan Wright, Kevin McLaughlin, Devin Toner, Dominic Ryan, Shane Jennings, Jamie Heaslip (capt).
Replacements: Aaron Dundon, Cian Healy, Mike Ross, Nathan Hines, Rhys Ruddock, Paul O'Donohoe, Ian McKinley, David Kearney.