John Hayes will win his 217th Munster cap when he starts against Connacht alongside the other Munster front rower who has also reached the 200th cap mark, Marcus Horan.
The second row berths will be filled by Donncha O'Callaghan and stand-in captain Mick O'Driscoll, who are both in line to join the 200 cap club in due course.
The experience up front is contrasted by a youthful back-line where Sean Scanlon makes his senior debut at full-back and Luke O'Dea, who scored on his debut against Edinburgh last month, will feature on the right wing.
MUNSTER (v Connacht): Sean Scanlon; Luke O'Dea, Keith Earls, Danny Barnes, Simon Zebo; Ian Keatley, Tomas O'Leary; Marcus Horan, Denis Fogarty, John Hayes, Donncha O'Callaghan, Mick O'Driscoll (capt), Billy Holland, Niall Ronan, Paddy Butler.
Replacements: Sean Henry, Dave Kilcoyne, BJ Botha, Ian Nagle, James Coughlan, Duncan Williams, Scott Deasy, Tom Gleeson.