In the pack hooker Adrian Flavin replaces Ethienne Reynecke in the front row and the departing Ray Ofisa moves to the replacements bench, making way for openside flanker Johnny O'Connor.
In the back-line, rising star Eoin Griffin's return to outside centre means Kyle Tonetti moves to the right wing, while speedster James Loxton is promoted to the bench.
Connacht are chasing their best ever league finish of eighth and a win over play-off contenders Glasgow will secure that historic result for the province.
Glasgow have a lot to play for though in their last match at Firhill and Connacht's talismanic back rower John Muldoon is under no illusions about the scale of the challenge that lies ahead:
"They'll be coming out all guns blazing but at the same time we're looking to cause an upset and finish a record eighth, that would be a very good return for us this season."
He added: "We're really looking to finish on a high and saying goodbye to some great servants of the province, that goes for everyone, from fellas like Henry (Fa'afili), who has been here for just a year, to the likes of Ray (Ofisa) who has been here for over six years.
"We'd like to give them the send-off they deserve and on top of that wish (CEO) Gerry Kelly the best of luck in his retirement as well, so we're really looking to a big performance on Saturday."
CONNACHT (v Glasgow Warriors): Gavin Duffy (capt); Kyle Tonetti, Eoin Griffin, Henry Fa'afili, Tiernan O'Halloran; Miah Nikora, Frank Murphy; Denis Buckley, Adrian Flavin, Ronan Loughney, Michael Swift, Mike McCarthy, John Muldoon, Johnny O'Connor, George Naoupu.
Replacements: Dermot Murphy, Stewart Maguire, Rodney Ah You, Michael Kearney, Ray Ofisa, Paul O'Donohoe, Matthew Jarvis, James Loxton.