Cullen partners Steven Sykes in the second row with Sean O'Brien joining fellow Ireland internationals Shane Jennings and Rhys Ruddock in the back row.
Eoin O'Malley continues at centre alongside Fergus McFadden who had a 100% kicking return in his 15-point haul in Italy.
David Kearney also takes his place alongside Fionn Carr - a try scorer against Benetton Treviso - and the returning Isa Nacewa.
Jonathan Sexton has been named on a strong replacements bench alongside the likes of fellow Ireland internationals Sean Cronin, Rob Kearney and Mike Ross.
Over 16,000 tickets have now been sold for Friday's game and tickets are still available to purchase online here and from the Leinster Rugby Store (Donnybrook), Spar (Donnybrook) and Ticketmaster outlets nationwide.
The Ticketmaster van (Simmonscourt Road) and ticket office (located inside the Anglesea Gate) will also be selling tickets at the RDS from 4pm on Friday.
LEINSTER (v Cardiff Blues): Isa Nacewa; David Kearney, Eoin O'Malley, Fergus McFadden, Fionn Carr; Ian Madigan, Isaac Boss; Cian Healy, Richardt Strauss, Nathan White, Leo Cullen (capt), Steven Sykes, Rhys Ruddock, Shane Jennings, Sean O'Brien.
Replacements: Sean Cronin, Heinke van der Merwe, Mike Ross, Damian Browne, Leo Auva'a, Eoin Reddan, Jonathan Sexton, Rob Kearney.