Brian O'Driscoll is progressing well after stepping up his rehab in recent weeks and may be fit for selection this week.
The province's captain Leo Cullen is ahead of schedule and may also complete his comeback to the panel, following Achilles surgery in late January.
Mike Ross will be assessed by the medical team after suffering a shoulder injury in Ireland's defeat to England at Twickenham and the province are hopeful that the Cork tighthead prop will return for the away trip to Munster later this month.
With a number of players unavailable for the visit of the Ospreys after their exertions with Ireland over recent weeks, the Leinster management may call upon some of the lesser used Six Nations squad members for Friday's game which could include the likes of Sean Cronin, Shane Jennings, David Kearney and Fergus McFadden.
Tickets sales for the Leinster v Ospreys encounter have passed the 16,700 mark. Tickets are on sale online here, and from the Leinster Rugby Store (Donnybrook), Spar (Donnybrook) and Ticketmaster outlets nationwide.