Rory Best and Stephen Ferris have been rested as part of the IRFU's player management programme, so Andi Kyriacou and Robbie Diack come in as their direct replacements at hooker and blindside flanker respectively.
Chris Henry is also rested by the Ulster management with Willie Faloon taking his place in the back row, but the rest of the pack remains unchanged.
In the backs, Craig Gilroy, who like Henry has played in all of Ulster's 10 games so far this season, gets a well-earned break from the action.
The one positional change sees Simon Danielli move from full-back to his customary wing position in place of Gilroy, while Adam D'Arcy is promoted from the bench to don the number 15 jersey.
Tim Barker, Mike McComish and Ian Whitten have been added to the replacements bench.
Giving his thoughts on Friday's opponents, Brian McLaughlin said: "Whenever you are playing a Scottish side you've got to make your breakdown as accurate and as positive as possible.
"The other thing is that with Scottish sides buzzing about all over the place, you've got to make sure you keep their forwards all in one place as much as possible.
"We've talked about varying little things, varying our lineouts and what we're doing off them. Hopefully that will help us as the game progresses."
The defeat at Leicester was one of Ulster's better performances this season to date, but McLaughlin insists there is still plenty to work on.
"Welford Road at the weekend was annoying. We had everything more or less right but we just made little errors at crucial time which cost us.
"We played through some fantastic phases but made mistakes in crucial areas. If we're going to go on and get to where we want to be as a team then we've got to eradicate those individual errors."
ULSTER (v Glasgow Warriors): Adam D'Arcy; Andrew Trimble, Darren Cave, Nevin Spence, Simon Danielli; Ian Humphreys, Paul Marshall; Tom Court, Andi Kyriacou, Declan Fitzpatrick, Johann Muller (capt), Dan Tuohy, Robbie Diack, Willie Faloon, Pedrie Wannenburg.
Replacements: Nigel Brady, Paddy McAllister, Adam Macklin, Tim Barker, Mike McComish, Ian Porter, Paddy Jackson, Ian Whitten.