Mike Kelliher of Young Munster will form a new centre partnership with the previously-capped Killian Lett, who has been in impressive form throughout the season for Division 1A leaders Clontarf.
There is an all new back-three with Cathal Quinn of Cork Constitution and Lansdowne's Cian Aherne named alongside Ballymena's Rodger McBurney.
The side is coached by UCC's Conor Twomey, who is assisted by David Murphy of De La Salle Palmerston.
The Ireland Club side captured the inaugural Dalriada Cup with a thrilling 32-30 win in Scotland last season.
Twomey's charges will also face the England Counties team in Preston Grasshoppers RFC on Friday, March 16.
IRELAND CLUB Team & Replacements (v Scotland Clubs XV, Ulster Bank Club International, Anglesea Road, Old Belvedere RFC, Friday, March 9, kick-off 6.30pm):
15. Rodger McBurney (Ballymena) *
14. Cian Aherne (Lansdowne) *
13. Killian Lett (Clontarf)
12. Mike Kelliher (Young Munster) *
11. Cathal Quinn (Cork Constitution) *
10. Craig Ronaldson (Lansdowne) *
1. Rob Sweeney (St. Mary's College)
2. Ger Slattery (Young Munster)
3. Christy Condon (Dolphin)
4. Philip Donnellan (Cork Constitution)
5. Fergal Walsh (Shannon)
6. Simon Crawford (Clontarf) (capt)
7. Barry O'Mahony (Clontarf)
8. Hugh Hogan (St. Mary's College)
16. Hugh McGrath (Young Munster) *
17. Risteard Byrne (UCD) *
18. Liam Og Murphy (Young Munster)
19. Frank Cogan (Clontarf)
20. Brian Slater (UCC) *
21. Barry Keeshan (Dolphin)
22. James Thompson (Ballynahinch) *
* Denotes uncapped player