Eoin McKeon makes up an all-Galway back row, wearing the number 8 jersey.
On the replacements bench, lock Aly Muldowney returns to the fray and the 20-year-old Academy back Darragh Leader has been brought in as cover.
Speaking about the westerners' preparations for this derby clash, head coach Pat Lam said: "Despite being boosted by the win last Saturday against the Dragons, we lost a couple of guys through that last game.
"It's hugely disappointing to have to plan without Dave (McSharry), especially on the back of losing our other midfielders Danie (Poolman), Craig (Ronaldson) and Kyle (Tonetti) to injury.
"We're delighted for Frank to achieve his 100th Connacht cap, especially after such a long road to recovery last season.
"Jake (Heenan) joins Willie Faloon on the injured list which is another huge loss to a crucial position for us. But John (Muldoon) has shown in the past that he has the skillset and experience to switch sides in the back row."
He added: "We're really looking forward to the game. These interprovincial games are huge occasions and a source of great pride for the players.
"It's a massive challenge as Munster are flying high at the top of the PRO12 table, they're topping their own Heineken Cup pool and we haven't beaten them down there since 1967!
"We have shown this season that if we go through the processes and bring heart to our game-plan, we can get the outcome we all want. That's what we have to do tomorrow."
CONNACHT (v Munster): Gavin Duffy; Fionn Carr, Robbie Henshaw, Eoin Griffin, Matt Healy; Dan Parks, Frank Murphy; Brett Wilkinson, Jason Harris-Wright, Nathan White, Michael Kearney, Craig Clarke (capt), Andrew Browne, John Muldoon, Eoin McKeon.
Replacements: David Heffernan, Denis Buckley, Rodney Ah You, Aly Muldowney, George Naoupu, Kieran Marmion, Jack Carty, Darragh Leader.