The changes are in keeping with last season's very successful squad rotation policy. Dan McFarland comes in for Adrian Clarke in the front row, Pieter Myburgh comes in for Christian Short in the second row and Paul Neville replaces John Muldoon. All three are in line to make their first starts of the season.
Mark McHugh will start at inside centre, with Niall O'Brien moving to the wing and Ted Robinson taking a place on the bench. John O'Sullivan comes in for Mick Carroll. Meanwhile Michael Swift comes into the squad for this first time this season after injury.
The game is live on BBC Wales and those of you who are used to watching the channel should take note of the later than normal kick off time of 7:35pm. Details of how to get BBC Wales on Sky Digital are available on the Connacht rugby web site www.connachtrugby.ie.
Connacht: David Slemen; Niall O'Brien, Matt Mostyn, Mark McHugh, Conor McPhillips, Paul Warwick, Tom Tierney; Dan McFarland, Bernard Jackman, Peter Bracken, Pieter Myburgh, Andrew Farley, Paul Neville, Matt Lacey, John O'Sullivan.
Replacements: John Fogarty, Adrian Clarke, Michael Carroll, Michael Swift, Eric Elwood, Conor O'Loughlin, Ted Robinson.