James Downey returns from injury and replaces the injured Mark McHugh at inside centre making his first appearance since the opening game against Glasgow. The final change is in the pack with John Fogarty replacing the injured Bernard Jackman.
There are a number of changes on the bench as well with Henry Bourke, Christian Short, John Muldoon and Justin Meagher all returning to the squad while Mike Walls will be among the replacements for the first time this season.
Bernard Jackman, Matt Mostyn, Mark McHugh, Tom Tierney, Michael Swift, Michael Carroll and Darren Yapp were all not considered due to injury.
Saturday's game will mark Connacht Rugby Ladies Day with all ladies attending being admitted for free to all areas of the ground.
Connacht: 15. David Slemen; 14. Niall O'Brien, 13. Paul Warwick, 12. James Downey, 11. Conor McPhillips; 10. Eric Elwood, 9. Conor O'Loughlin; 1. Dan McFarland, 2. John Fogarty, 3. Peter Bracken, 4. Pieter Myburgh, 5. Andrew Farley, 6.Paul Neville, 7. Matt Lacey, 8. John O'Sullivan.
Replacements: 16.Henry Bourke, 17. Adrian Clarke, 18. Christian Short, 19. John Muldoon, 20. Mike Walls, 21. Ted Robinson, 22. Justin Meagher.