The selected squad features a number of players who took part in the O2 Challenge - the first rugby match at the Aviva Stadium - back in July.
Ballymena's Luke Marshall, who was named man-of-the-match in that game and recently made his Ulster debut, will start at centre, while Dungannon clubman Paddy Jackson and UCD's Peter du Toit have been paired together at half-back.
Up front, Daniel Qualter from Buccaneers will partner Ian Henderson of Queen's University in the second row.
Lansdowne's Jordi Murphy, who featured in the Ireland Under-20 panel last season, will captain the side from the openside flank.
Indeed, Murphy, his Lansdowne club-mate Martin Moore and UCD hooker David Doyle all played for Ireland at last summer's IRB Junior World Championship in Argentina.
IRELAND UNDER-20 Team & Replacements (v Italy Under-20s, Friendly International Match, Donnybrook, Thursday, November 4, kick-off 2.30pm):
15. Michael Sherlock (Clontarf/Leinster)
14. Craig Gilroy (Dungannon/Ulster)
13. Alex Kelly (UCD/Leinster)
12. Luke Marshall (Ballymena/Ulster)
11. Sam Coghlan Murray (UCD/Leinster)
10. Paddy Jackson (Dungannon/Ulster)
9. Peter du Toit (UCD/Leinster)
Corey Hircock (Moulton College/Munster)
JJ Hanrahan (UL Bohemians/Munster)
Lukas Kunz (Garryowen/Munster)
Cathal Marsh (Dublin University/Leinster)
Mark Dolan (Corinthians/Connacht)
Aaron Spring (Sligo/Connacht)
James Rael Garryowen/Munster)
Kyle McCall (Ballynahinch/Ulster)
Dominic Gallagher (Dublin University/Ulster)
Shane Buckley (Garryowen/Munster)
David Heffernan (Lansdowne/Connacht)