Rob Kearney is also included, after making his comeback from illness, as are the likes of Devin Toner, Simon Keogh, Ronan McCormack, Trevor Hogan, Sean O'Brien and Fergus McFadden who were all involved last weekend's final Magners League game against the Dragons.
Meanwhile, the 'Blue Province' campaign is underway this week with clubs, schools, pubs and individuals eager to show their support for the team.
Over 50 clubs have signed up for the 'Blue Leinster' packs and anyone who can't make it to Edinburgh this weekend is encouraged to attend will their nearest participating club and get behind Michael Cheika's squad.
Primary and Secondary schools throughout Leinster are being encouraged to wear blue on Friday to show their support for the players.
As a result of unprecedented demand, flags and posters have been distributed to pubs around the province.
Anyone taking part in 'Blue Province', and decorating their home, school, local pub or rugby club should send in photos to firstname.lastname@example.org to be featured on www.leinsterrugby.ie.
LEINSTER Squad (v Leicester Tigers): Backs (12) - Chris Keane, Simon Keogh, Chris Whitaker, Jonathan Sexton, Luke Fitzgerald, Rob Kearney, Gordon D'Arcy, Fergus McFadden, Brian O'Driscoll, Shane Horgan, Girvan Dempsey, Isa Nacewa.
Forwards (14) - Cian Healy, Ronan McCormack, John Fogarty, Bernard Jackman, Stephen Knoop, Stan Wright, Leo Cullen, Trevor Hogan, Malcolm O'Kelly, Devin Toner, Rocky Elsom, Shane Jennings, Sean O'Brien, Jamie Heaslip.