2005 Lions Tour: Saturday, July 9New Zealand v Lions, Eden Park, Auckland, 8.10am Irish time (Live Sky Sports 1/RTE Radio 1)
Scotland's Gordon Bulloch - the Lions' midweek captain - takes Byrne's place on the bench.
The loss of Thompson is seen as a huge blow to head coach Sir Clive Woodward, whose team will be whitewashed if they lose for a third successive weekend.
Thompson played his way into the Lions' second Test line-up, after Aughrim man Byrne failed to find his lineout targets in the first Test in Christchurch.
NEW ZEALAND: Mils Muliaina; Rico Gear, Conrad Smith, Tana Umaga (Captain), Sitiveni Sivivatu; Luke McAlister, Byron Kelleher; Tony Woodcock, Keven Mealamu, Greg Somerville, Chris Jack, Ali Williams, Jerry Collins, Rodney So'oialo, Sione Lauaki.
Replacements: Derren Witcombe, Campbell Johnstone, James Ryan, Marty Holah, Justin Marshall, Nick Evans, Doug Howlett.
BRITISH & IRISH LIONS:
(15) Geordan Murphy (Leicester/Ireland)(14) Mark Cueto (Sale Sharks/England)(13) Will Greenwood (NEC Harlequins/England)(12) Gareth Thomas (Toulouse/Wales) (Captain)(11) Josh Lewsey (Wasps/England)(10) Stephen Jones (Clermont Auvergne/Wales)(9) Dwayne Peel (Llanelli Scarlets/Wales)(1) Gethin Jenkins (Cardiff Blues/Wales)
(16) Gordon Bulloch (Glasgow/Scotland)(17) Graham Rowntree (Leicester/England)(18) Martin Corry (Leicester/England)(19) Martyn Williams (Cardiff Blues/Wales)(20) Matt Dawson (Wasps/England)(21) Ronan O'Gara (Munster/Ireland)(22) Shane Horgan (Leinster/Ireland)
Referee: Jonathan Kaplan (South Africa)