Italian lock Carlo Del Fava picked up a neck injury in the opening game of the league, so Ireland 'A' international Ryan Caldwell claims the number 4 jersey and will partner new recruit Ed O'Donoghue.
In the back row, Kieron Dawson drops to the bench to allow promising player David Pollock to start alongside Matt McCullough and Robbie Diack.
Versatile back rower Thomas Anderson has been named in the squad and having played second row at Irish schools level, he could cover both the back row and the second row if needed.
This is Ulster's first away trip of the 2008/09 season and assistant coach Steve Williams will be hoping that his side can put in a big performance against the Blues.
"We have some very experienced players in our side who know what it is like to play away in Wales and they are hungry to come away with a win."
ULSTER (v Cardiff Blues): Clinton Schifcofske; Andrew Trimble, Darren Cave, Rob Dewey, Timoci Nagusa; Paddy Wallace, lsaac Boss; Justin Fitzpatrick, Rory Best (capt), BJ Botha, Ryan Caldwell, Ed O'Donoghue, Matt McCullough, David Pollock, Robbie Diack.
Replacements: Nigel Brady, Tom Court, Kieron Dawson, Thomas Anderson, Cillian Willis, Niall O'Connor, Bryn Cunningham.