In the forwards there are two changes in the front row with John Lyne starting at loosehead prop alongside Sean Cronin at hooker, while in the back row Colm Rigney comes in at number 8.
Second row David Gannon has been named on the replacements bench for the first time this season having recovered from a calf injury which had kept him out of contention since the new season began.
Meanwhile, Connacht's next home match against the Portugese national team has been rescheduled at the request of the IRFU and Rugby Portugal.
The game has been moved from Wednesday, November 5 to Sunday, November 9 (kick-off 6pm).
CONNACHT (v Edinburgh): Fionn Carr; Aidan Wynne, Gavin Duffy, Mel Deane, John Hearty; Ian Keatley, Frank Murphy; John Lyne, Sean Cronin, Robbie Morris, Michael Swift, Andrew Farley, John Muldoon (capt), Johnny O'Connor, Colm Rigney.
Replacements: Adrian Flavin, Ronan Loughney, Andrew Browne, David Gannon, Kieran Campbell, Andy Dunne, Troy Nathan.