Academy out-half Jack Carty will captain the side in Llanelli, having made his second RaboDirect PRO12 appearance in the second half of Connacht's defeat away to Benetton Treviso last Friday.
Following the round 1 tie, the Eagles will welcome Rotherdam Titans to the Sportsground on Saturday week (October 19).
Kick-off is at 2.30pm and Connacht Season Ticket holders are granted access to all of the Eagles' home British & Irish Cup games.
CONNACHT EAGLES (v Llanelli): Tadhg Leader; Brian Murphy, Rory Parata, David McSharry, David Panter; Jack Carty (capt), Marcus Walsh; Denis Buckley, David Heffernan, Finlay Bealham, David Nolan, Michael Kearney, Mata Fifita, James Connolly, Daniel Qualter.
Replacements: Risteard Byrne, Saba Meunargia, Ultane Dillane, Conor Kindregan, Eoghan Masterson, Caolin Blade, Ciaran Gaffney.