In the injury-enforced absence of Jonathan Sexton, second row James Ryan will become the 107th player to captain Ireland when he leads the side in London.
The 24-year-old Dubliner, who previously skippered the Ireland Under-20s, was the on-field captain after Sexton went off during the first half of last week’s win over Wales.
Ryan is the fourth youngest Ireland captain of the professional era, following on from Peter O’Mahony, Brian O’Driscoll (both 23) and Paul O’Connell (24).
Quinn Roux’s strong performance against Wales earns him a second successive start at lock, with an unchanged tight five completed by Cian Healy, Ronan Kelleher and Andrew Porter.
CJ Stander returns to the blindside berth, which he last filled against Scotland in February. O’Mahony shifts to openside and Caelan Doris, the player-of-the-match last time out, continues at number 8.
On the back of his first start last week, Jamison Gibson-Park retains the number 9 jersey. It is an all-Leinster half-back pairing as Ross Byrne, whose only previous start was against England last year, replaces the injured Sexton.
The final two changes see Bundee Aki and Keith Earls come back into the starting XV. Aki, a try scorer against England in August 2019, replaces the injured Robbie Henshaw in midfield where he partners Chris Farrell.
Having recovered from a back injury, Earls will win his 86th cap on the right wing. It is a second successive start at full-back for Hugo Keenan, while James Lowe continues on the left following his try-scoring debut.
Ulster duo Iain Henderson and Jacob Stockdale, who both missed the Wales game, return to the matchday 23 as replacements.
The selected bench also includes Rob Herring, Conor Murray, Finlay Bealham and the newly-capped trio of Ed Byrne, Will Connors and Billy Burns.
Speaking ahead of this weekend’s clash, which will be shown live on RTÉ One, Channel 4 and Amazon Prime (UK only), Andy Farrell said:
He deserves it, Ross deserves the chance. It’s like others. How do you find out about how they cope with the big games and the big occasions unless you give them a chance?
“We can’t just give them a chance of picking them in a squad and just training the whole time. Ross has been involved in some big games for Leinster and this is his chance to go to Twickenham and be part of a great team performance as well.
“I saw something nine months ago when we went into the Six Nations, the start of the Six Nations, where James Ryan started to think probably, while people are talking about me in this vein, maybe I should start doing something about it.
“He has 100% come to the fore in his curiousness about how he wants to lead, etc. I’ve been super impressed over the last nine months with how he handles himself, first and foremost, and how he interacts and thinks about others as well.”
He added: “You can’t make promises. Not got a crystal ball. What I do know is that this is a different group, we’ve new combinations all over the field that are coming together and learning from these types of experiences.
“I can’t wait for them to get out there and show what they can do. We’re concentrating on ourselves. We gain confidence in how we prepare and making sure we understand how we want to play the game and that’s how we’re going in.”
Meanwhile, England boss Eddie Jones has also made four personnel changes to the side that saw off George on a 40-0 scoreline in the opening round.
Young flankers Tom Curry (22) and Sam Underhill (24) return to the starting XV, reuniting the back row trio from last year’s Rugby World Cup final against South Africa.
Saracens’ Maro Itoje reverts to his regular lock position as a result, while props Ellis Genge and Will Stuart make way for Lions duo Mako Vunipola and Kyle Sinckler in the front row.
The selected back-line is led by captain Owen Farrell and Ben Youngs, with the Leicester Tigers scrum half the most experienced member of the squad with 101 England caps.
Worcester Warriors’ Ollie Lawrence is a notable inclusion at outside centre, where he makes his second successive start. George Ford has recovered from an Achilles injury to take a bench spot.
Autumn Nations Cup Fixtures/Results
ENGLAND: Elliot Daly (Saracens); Jonathan Joseph (Bath), Ollie Lawrence (Worcester Warriors), Henry Slade (Exeter Chiefs), Jonny May (Gloucester); Owen Farrell (Saracens) (capt), Ben Youngs (Leicester Tigers), Mako Vunipola (Saracens), Jamie George (Saracens), Kyle Sinckler (Bristol Bears), Maro Itoje (Saracens), Joe Launchbury (Wasps), Tom Curry (Sale Sharks), Sam Underhill (Bath), Billy Vunipola (Saracens.
Replacements: Tom Dunn (Bath), Ellis Genge (Leicester Tigers), Will Stuart (Bath), Jonny Hill (Exeter Chiefs), Ben Earl (Bristol Bears), Dan Robson (Wasps), George Ford (Leicester Tigers), Max Malins (Bristol Bears).
IRELAND: Hugo Keenan (UCD/Leinster); Keith Earls (Young Munster/Munster), Chris Farrell (Young Munster/Munster), Bundee Aki (Galwegians/Connacht), James Lowe (Leinster); Ross Byrne (UCD/Leinster), Jamison Gibson-Park (Leinster); Cian Healy (Clontarf/Leinster), Ronan Kelleher (Lansdowne/Leinster), Andrew Porter (UCD/Leinster), Quinn Roux (Galwegians/Connacht), James Ryan (UCD/Leinster) (capt), CJ Stander (Shannon/Munster), Peter O’Mahony (Cork Constitution/Munster), Caelan Doris (St. Mary’s College/Leinster).
Replacements: Rob Herring (Ballynahinch/Ulster), Ed Byrne (UCD/Leinster), Finlay Bealham (Buccaneers/Connacht), Iain Henderson (Academy/Ulster), Will Connors (UCD/Leinster), Conor Murray (Garryowen/Munster), Billy Burns (UIster), Jacob Stockdale (Lurgan/Ulster).
Referee: Pascal Gauzere (France)
Assistant Referees: Mathieu Raynal, Alexandre Ruiz (both France)
Television Match Official: Nigel Owens (Wales)
Pre-Match Quotes: James Ryan (Ireland) –
Huge honour for me. Looking forward to it. Probably the great thing about it is that I won’t be on my own.
“There’s guys like Peter O’Mahony there, Hendy (Iain Henderson), Earlsy (Keith Earls), a huge amount of experience. Johnny (Sexton) is in for the week as well.
“We’ll very much be driving things together this week, as we usually would. It’s an exciting week for all of us. Even when Johnny is captain, we tend to drive the week as a collective.
“There’s a core group of us. It’s the same as it is this week, but certainly having guys like Peter, Hendy, Earlsy there will make my job a lot easier.
“Of course we’re going to need intensity, obviously. Set piece and defence is massive for us this week and I think it’s huge at this level, especially going away from home.
“If you look at that game that we lost (24-12 in February), obviously we didn’t start well. We’ve got to start well at this level.
“We’ve got to start well going away playing in Twickenham, because if you give a side like England momentum, they’re very, very hard to stop. They’re areas of the game that are really big for us this week.”
Eddie Jones (England) –
I’ve picked the strongest team possible for the most important game of our season. We have the highest respect for the Ireland and their coach Andy Farrell.
“They’ve had good preparation with two wins and a dominant display against Wales, and we will need to be at our best on Saturday.
“We’ve trained well this week, we’re expecting a tough, physical game against Ireland and we’ve reflected that in our sessions. We’ll look to lift our performance even higher and are looking forward to a really good game of rugby.”
Pre-Match Links –
Head-To-Head: Ireland v England
Ryan Embraces ‘Huge Honour’ Of Captaining Ireland This Week
In Pics: Ireland Captain’s Run At Twickenham
Stander: Caelan’s Brought Energy And Something Different
Murphy: We’ve Added More Variety And Options To Our Kicking Game
Recent Meetings –
2018: NatWest 6 Nations: England 15 Ireland 24, Twickenham Stadium
2019: Guinness Six Nations: Ireland 20 England 32, Aviva Stadium; Rugby World Cup Warm-Up: England 57 Ireland 15, Twickenham Stadium
2020: Guinness Six Nations: England 24 Ireland 12, Twickenham
Support Ireland on www.facebook.com/irishrugby or search #ENGvIRE, #ShouldertoShoulder and #TeamOfUs on www.twitter.com/irishrugby.