Division 1A leaders Old Belvedere welcome second placed Terenure College to Ollie Campbell Park in a mouth-watering Dublin derby. Belvo arrive following an impressive 24-7 victory away to Cork Constitution, while Terenure have won three consecutive Dublin derbies, most recently defeating UCD 47-25. Belvo won 30-24 at this venue last December, although Terenure claimed the reverse fixture 27-19.
Third placed Clontarf travel to the Aviva Stadium Back Pitch to face Lansdowne, who won 31-19 when the sides met there in March. Both arrive following victories, with Clontarf overcoming Ballynahinch and Lansdowne defeating Young Munster.
St Mary's College welcome Young Munster to Templeville Road looking to build on their victory over Old Wesley, although the Cookies won 22-20 on their last visit. UCD host Old Wesley in another Dublin derby, with both seeking a response to defeat. Wesley won 29-16 on their last league visit to Belfield in April 2010.
Ballynahinch and Cork Constitution complete the programme at Ballymacarn Park in a crucial bottom two encounter. Hinch seek their second home victory, while Con hope to avoid three consecutive defeats.
Division 1B leaders Blackrock College welcome fourth placed Highfield to Stradbrook chasing a third straight victory. Rock remain unbeaten at home, while Highfield arrive following the abandonment of their Cork derby against UCC due to a local power issue. The visitors won 27-15 at Stradbrook last October.
Second placed Naas travel to College Park to face Dublin University, seeking consecutive victories after overcoming City of Armagh. Trinity, meanwhile, hope to bounce back from defeat to Instonians and repeat last season's league double over Naas.
Third placed Instonians visit MU Barnhall at Parsonstown chasing a fourth consecutive victory. The sides meet in Division 1B for the first time, with Barnhall having won their previous home encounter 35-31 in January 2025, the game is live on IrishRugby+
Nenagh Ormond welcome bottom placed UCC for a Munster derby, renewing a rivalry that produced Nenagh's dramatic 36-33 promotion victory in April 2025. City of Armagh host Garryowen at the Palace Grounds, with both clubs seeking a return to winning ways and the visitors hoping to repeat last season's double.
Division 2A leaders Cashel travel to the Thomond Park Back Pitch for a Munster derby against Shannon, having edged Dungannon 21-20 last weekend. Cashel won 26-19 on their previous visit, although Shannon took the spoils in the reverse fixture.
Second placed Ballymena visit third placed Dungannon for a heavyweight Ulster derby at Stevenson Park. Both suffered their first defeats last weekend, with Ballymena seeking their first AIL victory at the venue since December 2009.
Galway Corinthians travel to Queen's University chasing a third straight victory, while the students hope to build on their win over UL Bohemian. Their last AIL meeting at the Dub ended in a 38-28 Queen's victory in April 2018.
Wanderers host Greystones in a Leinster derby at Merrion Road, chasing a fourth consecutive victory after their impressive success against Ballymena. Bottom placed Galwegians welcome UL Bohemian to Crowley Park, hoping to build on their opening victory while Bohs seek to avoid a third straight defeat.
Division 2B North leaders Malone travel to Estuary Road to face ninth placed Malahide, chasing a sixth consecutive victory. Malone remain the division's only unbeaten side following their hard fought success over Clogher Valley, while Malahide hope to recover from a dramatic late defeat to Rainey.
Second placed Enniskillen travel to The Cran to face third placed Clogher Valley in a huge local derby. Separated by approximately 17 miles, the neighbours meet in the AIL for the first time. Enniskillen have enjoyed a remarkable debut campaign, recording four victories, while Clogher seek an immediate response to their first defeat.
Ballyclare visit Skerries in a repeat of their April 2025 promotion play-off semi-final, which Skerries won 27-10 at Holmpatrick. Both clubs arrive following defeats and will be determined to get back on track.
Banbridge welcome Sligo to Rifle Park chasing a third consecutive victory after recovering from three opening defeats. Sligo also returned to winning ways last weekend, edging Navan in a tight encounter.
Bottom placed Navan host Rainey at Balreask Old, with the visitors hoping to build on their dramatic first victory against Malahide. Navan narrowly lost 15-14 to Sligo and will be eager to close the gap on the clubs above them.
Division 2B South leaders Clonmel travel to Kilballyowen Park to face Bruff in a Munster derby, seeking a sixth consecutive victory. Clonmel are now the division's only unbeaten side after overcoming Old Crescent, although Bruff won 19-18 when the sides last met at this venue in January.
Second placed Bective Rangers welcome Monkstown to Energia Park for a Dublin derby. Bective chase a fifth straight victory and won last season's corresponding fixture 34-21, while Monkstown seek to avoid three consecutive defeats.
Old Crescent welcome Thomond to Takumi Park for an all Limerick clash. Crescent suffered their first defeat against Clonmel last weekend and will be determined to respond, while Thomond hope to end a three game losing run. Crescent won both AIL meetings when the sides last shared a division in 2016/17.
Fourth placed Midleton host bottom placed Enniscorthy at Towns Park, chasing a third consecutive victory and looking to preserve their unbeaten home record. Enniscorthy remain without a win but produced a spirited performance against Bruff last weekend.
Buccaneers welcome Dolphin to Dubarry Park, with the hosts looking to build on their victory over Monkstown. Dolphin, meanwhile, seek to avoid a fifth consecutive defeat and claim their first win at the venue since February 2016.