Men's Division 1A
A blockbuster Dublin derby headlines the Division 1A action as table toppers Old Belvedere welcome second placed Terenure College to Ollie Campbell Park, with both sides looking to strengthen their position at the summit.
Third placed Clontarf travel to the Aviva Stadium back pitch to face sixth placed Lansdowne in another capital clash, while fourth placed St Mary's College welcome eighth placed Young Munster to Templeville Road.
Fifth placed UCD host seventh placed Old Wesley at Belfield in another Dublin derby, while a crucial encounter at the foot of the table sees bottom placed Ballynahinch welcome ninth placed Cork Constitution to Ballymacarn Park.
Women's Division 1A
A Dublin derby takes centre stage as leaders Old Belvedere welcome third placed Blackrock College to Ollie Campbell Park in one of the standout fixtures of the weekend.
Second placed UL Bohemian head west to Crowley Park to face fifth placed Galwegians, looking to maintain their challenge at the top of the standings.
Elsewhere, fourth placed Railway Union welcome bottom of the table Wicklow to Park Avenue in an all Leinster encounter, with the visitors aiming to improve their fortunes.
Men's Division 1B
Division 1B leaders Blackrock College welcome fourth placed Highfield to Stradbrook in a key clash at the top end of the table, while second placed Naas travel to College Park to face fifth placed Dublin University in a Leinster derby.
Third placed Instonians make the trip to Parsonstown to take on seventh-placed MU Barnhall, a game live on IrishRugby+ while sixth placed Nenagh Ormond head south for a Munster derby against bottom of the table UCC at the Mardyke.
Elsewhere, eighth placed City of Armagh welcome ninth placed Garryowen to the Palace Grounds, with both sides eager to climb away from the lower reaches of the standings.
Women's Division 1B
A top of the table encounter headlines the Women's Division 1B action as leaders Enniskillen welcome second placed MU Barnhall, with the two newly promoted sides meeting for the first time since stepping up to the division.
Third placed Ennis will be aiming to bounce back from their first defeat of the campaign when they travel to Rathoe Road to face fifth placed Tullow.
Bottom of the table Cooke get the weekend's action underway when they welcome fourth placed Ballincollig to Shaw's Bridge, with both sides looking to secure valuable league points.
Men's Division 2A
Division 2A leaders Cashel travel to Limerick for a Munster derby against eighth placed Shannon on the Thomond Park back pitch, while a mouth watering Ulster derby sees third placed Dungannon welcome second placed Ballymena to Stevenson Park in a crucial early season encounter.
Fourth placed Galway Corinthians make the trip north to face sixth placed Queen's University at Dub Lane, while fifth placed Wanderers welcome seventh placed Greystones to Merrion Road for a Leinster derby.
At the foot of the table, ninth placed UL Bohemian travel to Crowley Park to face bottom placed Galwegians, with both sides eager to secure valuable points in their battle to move up the standings.
Men's Division 2B North
Table toppers Malone travel to Estuary Road to face ninth placed Malahide, while a huge local derby sees second placed Enniskillen make the short trip to the Cran to face third placed Clogher Valley in the sides' first ever AIL meeting.
Fourth placed Ballyclare head to Holmpatrick to take on sixth placed Skerries, while fifth placed Banbridge welcome seventh placed Sligo to Rifle Park.
Elsewhere, eighth placed Rainey travel to Balreask Old to face bottom of the table Navan, looking to build on the momentum of their first victory of the campaign.
Men's Division 2B South
Division 2B South leaders Clonmel travel to Kilballyowen Park for a Munster derby against fifth placed Bruff, while second placed Bective Rangers welcome sixth placed Monkstown to Energia Park in an intriguing Dublin derby.
Third placed Old Crescent will be aiming to bounce back from their first defeat of the season when they host eighth placed Thomond at Takumi Park in an all Limerick clash.
Fourth placed Midleton welcome bottom of the table Enniscorthy to Towns Park, while seventh placed Buccaneers host ninth placed Dolphin at Dubarry Park, with both sides looking to improve their positions in the standings.
