Men's Division 1A
Table toppers Old Belvedere will look to build on last weekend's victory when they travel to Temple Hill to face ninth placed Cork Constitution, while second placed Terenure College chase a third consecutive Dublin derby win when they welcome UCD to Lakelands.
Fourth placed Clontarf will be eager to return to winning ways when they host bottom of the table Ballynahinch at Castle Avenue, with the visitors arriving full of confidence following their first victory of the campaign.
Fifth placed Old Wesley welcome sixth placed St Mary's College to Energia Park following contrasting Round 4 results, while seventh placed Young Munster host eighth placed Lansdowne at Tom Clifford Park, with both sides looking to bounce back from defeats last weekend.
Women's Division 1A
Division 1A of the Women's returns following a short break, with a mouth watering Dublin derby between table toppers Old Belvedere and fifth placed Railway Union headlining the action at Park Avenue, kicking off at 2:30pm.
Third placed Blackrock College welcome fourth placed Galwegians to Stradbrook, with both sides looking to build momentum following contrasting results in their previous outings.
Elsewhere, second placed UL Bohemian travel to Ashtown Lane for the late kick-off against bottom of the table Wicklow, who remain in search of their first victory of the campaign.
Men's Division 1B
Division 1B leaders Highfield get the weekend underway under the Friday night lights when they welcome bottom of the table UCC to Woodleigh Park for a local derby.
Second placed Dublin University travel north to face seventh placed Instonians at Shaw's Bridge in a 1pm kick-off on Saturday, while third placed Blackrock College head south to Dooradoyle to take on ninth placed Garryowen.
Fourth placed Naas welcome fifth placed City of Armagh to Forenaughts in an intriguing clash between two sides looking to strengthen their positions in the standings, while sixth placed Nenagh Ormond host eighth placed MU Barnhall at New Ormond Park.
Women's Division 1B
An all Leinster encounter gets the Women's Division 1B action underway at 3pm, as fourth placed MU Barnhall welcome third placed Tullow to Parsonstown.
A Munster derby sees bottom of the table Ballincollig host leaders Ennis at Tanner Park, with the Cork side aiming to secure their first victory of the campaign.
An Ulster derby completes the weekend's fixtures, as Cooke and Enniskillen meet for the first time in the AIL at Shaw's Bridge, with the encounter streamed live on IrishRugby+.
Men's Division 2A
Division 2A leaders Ballymena return to Eaton Park chasing a fifth consecutive victory when they welcome fifth placed Wanderers, while second placed Dungannon put their unbeaten record on the line with a trip to Spafield to face third placed Cashel in a standout top three clash.
Fourth placed Galway Corinthians host eighth placed Shannon in Creggs, while sixth placed Queen's University travel to Limerick to face ninth placed UL Bohemian.
Elsewhere, seventh placed Greystones welcome bottom of the table Galwegians to Dr Hickey Park, with the visitors still searching for their opening win of the season.
Men's Division 2B North
A blockbuster Ulster derby headlines the Division 2B North action as unbeaten leaders Clogher Valley travel to Gibson Park to face second placed Malone, with both sides looking to preserve their perfect starts to the campaign.
Third placed Ballyclare welcome sixth placed Banbridge to the Cloughan, while fourth placed Enniskillen will aim to bounce back from their first defeat of the season when they host fifth placed Skerries.
Seventh placed Sligo welcome Navan to Hamilton Park following contrasting results last weekend, while bottom of the table Rainey host Malahide at Hatrick Park, still seeking their first victory of the campaign.
Men's Division 2B South
A huge Munster derby takes centre stage at Ard Gaoithe as unbeaten leaders Clonmel welcome second placed Old Crescent, with both sides aiming to maintain their perfect starts to the season.
Third placed Bective Rangers travel to Liam Fitzgerald Park to renew acquaintances with seventh placed Thomond, while fourth placed Midleton head to Virgin Media Park for an all Cork encounter against eighth placed Dolphin.
Fifth placed Bruff travel to face bottom of the table Enniscorthy, who remain in search of their first win, while sixth placed Monkstown welcome ninth placed Buccaneers, with both sides eager to bounce back from defeats in Round 4.
