A top of the table Dublin derby between Clontarf and Old Belvedere headlines the Division 1A action, while the fiercely contested D6W rivalry between St Mary's College and Terenure College adds further intrigue to another action-packed weekend.
There is knockout rugby on the agenda too, with the opening round of the 2026/27 Energia Men's Junior Cup getting underway, as familiar contenders return and a number of newcomers prepare to make their competition debuts.
Men's Division 1A
A blockbuster Dublin derby sees table toppers Clontarf travel to second placed Old Belvedere, with the visitors chasing a fourth straight win following their emphatic 61-15 victory over UCD.
Another fierce rivalry is renewed at Templeville Road, where fifth placed St Mary's College host Terenure College in the D6W derby, with the visitors seeking their first league win at the venue since 2017.
Fourth placed UCD welcome eighth placed Cork Constitution, who are unbeaten in their last eight visits to the UCD Bowl, while sixth placed Young Munster travel to ninth placed Old Wesley for the sides' first top flight meeting since 1997. Elsewhere, seventh placed Lansdowne head north to face bottom of the table Ballynahinch in a contest streamed live on IrishRugby+.
Men's Division 1B
Leaders Naas travel to Shaw's Bridge to face eighth placed Instonians, seeking their first AIL victory at the venue, while second placed Highfield aim to maintain their impressive start when they visit seventh placed MU Barnhall.
Third placed Nenagh Ormond head to College Park to face Dublin University, with both sides looking to bounce back from their first defeats of the campaign.
Just score difference separates fourth placed City of Armagh and fifth placed Blackrock College ahead of their meeting at Stradbrook, while a Munster derby at the foot of the table sees bottom placed UCC welcome ninth placed Garryowen to the Mardyke.
Men's Division 2A
Unbeaten leaders Cashel travel to fifth placed Wanderers, who completed a league double over the Tipperary side last season, while second placed Ballymena head west to face bottom of the table Galwegians at Crowley Park.
Third placed Dungannon aim to make it four wins from four when they welcome eighth placed Shannon to Stevenson Park, while fourth placed Galway Corinthians travel to Annacotty to face seventh placed UL Bohemian, looking to bounce back from their first defeat. Elsewhere, sixth placed Queen's University host ninth placed Greystones at the Dub, with both sides eager to return to winning ways.
Division 2B North
Table toppers Ballyclare will aim to preserve their perfect start when they welcome bottom placed Navan to the Cloughan for the sides' first ever AIL meeting. Second placed Enniskillen also chase a fourth straight victory when they host seventh placed Banbridge in their first AIL Ulster derby.
Third placed Malone travel to eighth placed Rainey seeking a fourth consecutive maximum points haul, while fourth placed Clogher Valley look to extend their unbeaten run away to Skerries. Sixth placed Sligo will be hoping to build on their opening win when they travel to Estuary Road to face ninth placed Malahide.
Division 2B South
Leaders Clonmel welcome sixth placed Thomond to Ard Gaoithe chasing a fourth consecutive maximum points victory, while second placed Old Crescent have the same target when they host bottom of the table Enniscorthy in the sides' first AIL meeting.
Third placed Bective Rangers travel to ninth placed Buccaneers for their first league encounter since 2007, while fourth placed Midleton welcome fifth paced Monkstown, who have won the last three meetings between the sides. A Munster derby rounds off the action as eighth placed Bruff host seventh placed Dolphin at Kilballyowen Park, with both teams looking to end losing runs.
Energia Men's Junior Cup
The opening round of the 2026/27 Energia Men's Junior Cup gets underway this weekend, with last season's beaten finalists Dromore hosting Creggs in a rematch of their memorable semi-final encounter, which Dromore won 32-21.
Last season's quarter-finalists Wicklow travel to returning side Mallow, while fellow quarter-finalists Suttonians face a trip to 2019/20 champions Kilfeacle & District. Bandon head north to meet Portadown, who return to the competition for the first time since 2017.
Former AIL side Ballina welcome debutants Clonakilty to Heffernan Park, while fellow newcomers Lurgan travel to face Tullamore. Omagh Academicals also make their competition debut away to Dunmore, while Boyne return to the Junior Cup for the first time since 2010 when they host Ballinasloe, who make their first appearance since 2015.