Men's Division 1A
The long awaited rematch of St Mary's College and Clontarf is a headline maker in 1A this weekend. Clontarf sit third after victory at home to Old Wesley last weekend, and another Dublin derby has them travelling to 5th placed Mary's. Another all Dublin meeting will see 4th placed UCD welcome 6th placed Lansdowne to Belfield, while Old Wesley host their first top flight fixture in the capital since 1997 as they take on Cork Con.
Elsewhere in the capital this weekend, table toppers Old Belvedere welcome Ballynahinch, while second hosts bottom in Lakelands Park, as Terenure College welcome Young Munster.
Watch the meeting of St Mary's College and Clontarf live on IrishRugby+.
Division 1B
After an exciting opening round of fixtures, Round 2 in 1B serves up the meeting of third placed Nenagh Ormond and table toppers Naas, who both recorded victory on the opening weekend. Fourth placed Garryowen are on the road to Dublin University aiming to build on their home win last weekend.
Instonians welcome Highfield to Shaw's Bridge as the pair seek their first win of the season, MU Barnhall play hosts for the first time in Division 1B as they welcome City Of Armagh for the first time in nine years. Second placed Blackrock College are on the road to take on UCC in the Mardyke elsewhere.
Division 2A
Crowley Park will witness 2A rugby for the first time in seven years on Saturday as Galwegians welcome Shannon, with the pair aiming to record their first win. Second hosts First at The Dub, Cashel make the trip to Queen's University, while third placed Galway Corinthians travel to Greystones.
Fifth placed Ballymena travel south to meet bottom placed UL Bohemian, while Wanderers have their first home game of the campaign against fourth placed Dungannon.
Division 2BN
After a closely fought opening to the season, Round 2 in Division 2B North is set for another big weekend of fixtures. Clogher Valley sit top going into the weekend and travel to Navan, who are seeking their first win of the season. Second placed Skerries will also be seeking another win as they too are on the road as they travel to Banbridge.
It will be a first away trip for Enniskillen, they had a dream debut last weekend and aim for back to back wins against bottom placed Malahide. Rainey host Ballyclare in back to back Ulster derbies for the home side, while Sligo take on Malone in their first home tie of the campaign.
Division 2BS
Having started the season off with a win, table toppers Bruff have their first home game of the season as Bective Rangers make the trip to Limerick. Second placed Dolphin also recorded a maximum haul last weekend and take on third placed Clonmel in a big all Munster clash.
Old Crescent also secured a bonus point win last weekend and welcome Monkstown to Takumi Park, Midleton also aim to continue winning ways as they host Buccaneers, while Enniscorthy and Thomond meet in Alcast Park, with both looking for their first win of the campaign.