Ireland centre Garry Ringrose, who was set to win his 50th cap on Saturday, has been ruled out of the game after picking up an injury. Stuart McCloskey will start in the centre at 12 alongisde Bundee Aki who moves to 13. Jimmy O'Brien comes in to the replacements. O'Brien made his Ireland debut in the Bank of Ireland Nations series against South Africa when he was added to the bench as McCloskey replaced Robbie Henhsaw in the starting XV. The following week he started at fullback against Fiji and then switched to to the wing a week later against Australia.

IRELAND Team (v Italy, Guinness Six Nations Championship, Stadio Olimpico, Rome, Saturday 25^th February, 2023, KO 14.15 (IST)

15. Hugo Keenan (Leinster/UCD) 27 caps 14. Mack Hansen (Connacht/Corinthians) 11 caps 13. Bundee Aki (Connacht/Galwegians) 43 caps 12. Stuart McCloskey (Ulster/Bangor) 11 caps 11. James Lowe (Leinster) 17 caps 10. Ross Byrne (Leinster/UCD) 16 caps 9. Craig Casey (Munster/Shannon) 9 caps 1. Andrew Porter (Leinster/UCD) 50 caps 2. Ronan Kelleher (Leinster/Lansdowne) 19 caps 3. Finlay Bealham (Connacht/Buccaneers) 29 caps 4. Iain Henderson (Ulster/Academy) 70 caps 5. James Ryan (Leinster/UCD) 50 caps (c) 6. Caelan Doris (Leinster/St Mary’s College) 25 caps 7. Josh van der Flier (Leinster/UCD) 47 caps 8. Jack Conan (Leinster/Old Belvedere) 35 Replacements 16. Dan Sheehan (Leinster/Lansdowne) 14 caps 17. Dave Kilcoyne (Munster/UL Bohemians) 50 caps 18. Tom O’Toole (Ulster/Ballynahinch) 6 caps 19. Ryan Baird (Leinster/Dublin University) 8 caps 20. Peter O’Mahony (Munster/Cork Constitution) 91 caps 21. Conor Murray (Munster/Garryowen) 102 caps 22. Jack Crowley (Munster/Cork Constitution) 2 caps 23. Jimmy O'Brien (Leinster/Naas) 3 caps