The Munster team to face Edinburgh in Saturday's RaboDirect PRO12 encounter at Meggetland (kick-off 5pm) shows 11 changes to the side that started against Toulon last weekend.
After the Ospreys' defeat to Zebre last night Munster are now guaranteed a RaboDirect PRO12 semi-final place along with Leinster and Glasgow Warriors.
But Rob Penney's men will continue to battle for home advantage in the play-offs with the Edinburgh challenge up first this weekend.
A new-look front row sees James Cronin and John Ryan pack down either side of hooker Duncan Casey. Having featured last weekend against Toulon, Cronin makes his first start for the province since the Benetton Treviso game in March.
The familiar duo of Paul O'Connell and Donncha O'Callaghan combine in the second row, while Tommy O'Donnell and Paddy Butler return to the back row alongside blindside flanker CJ Stander.
Last time out in the league Butler impressed with a man-of-the-match performance against Connacht, securing the bonus point try at the Sportsground.
After an excellent rehab on a groin injury, JJ Hanrahan suffered no ill-effects from the last 20 minutes of the Heineken Cup semi-final in Marseille and starts alongside Conor Murray in the half-backs.
Denis Hurley and Johne Murphy, both of whom signed new contracts with Munster this week, form the centre partnership. Meanwhile, Simon Zebo switches to full-back with Andrew Conway and Gerhard van den Heever introduced on the wings.
The province take a strong bench to Scotland that includes five of last weekend's starting team, and Luke O'Dea is named in his first senior squad of the season after overcoming a string of injuries.
MUNSTER (v Edinburgh): Simon Zebo, Gerhard van den Heever, Johne Murphy, Denis Hurley, Andrew Conway; JJ Hanrahan, Conor Murray; James Cronin, Duncan Casey, John Ryan, Donncha O'Callaghan, Paul O'Connell (capt), CJ Stander, Tommy O'Donnell, Paddy Butler.
Replacements: Damien Varley, David Kilcoyne, Alan Cotter, David Foley, James Coughlan, Duncan Williams, Ian Keatley, Luke O'Dea.
The provinces claimed 19 out of a possible 20 points over the weekend, as Munster and Leinster kept up the Irish 1-2 at the top of the GUINNESS PRO12, Ulster moved up to fifth place and Connacht's second successive home win also saw them gain ground.
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Speaking to Rob Murphy after Connacht's PRO12 victory over the Dragons, head coach Pat Lam said: "There are some things to learn from, but we're pleased to start with a win. When you consider nine in that starting group are under 23, it's good to see some of those talented guys get a chance - particularly the new ones."
Irish Rugby TV ventured west to cover the launch of Mazda's continued support of Connacht Rugby. We hear from new arrival and Mazda Ambassador Mils Muliaina, Kieran Marmion, Jake Heenan and former captain Gavin Duffy.
Looking forward to the new GUINNESS PRO12 season, Connacht captain John Muldoon said: "We've a lot of younger guys who have big years ahead of them and a few big name signings who will hopefully be able to fit into the system and work hard among the ethos of Connacht Rugby."
Irish Rugby TV was at the launch of the GUINNESS PRO12 and we caught up with Jamie Heaslip, Pat Lam, John Muldoon, Matt O'Connor and Rory Sheridan of Diageo as the new sponsor gets ready to kick off an exciting season.
Speaking during Connacht's training trip to Ballinrobe RFC, captain John Muldoon said: "It's great to see the jerseys and the people coming out to support us today. Long may it continue because we're not a Galway team, we're a Connacht team and that's what we want to push and that's why we come out on these days out."
Young hooker David Heffernan, who extended his current deal with Connacht in April, enjoyed a trip back to his native Mayo as Pat Lam's men held an open training session at Ballinrobe RFC earlier this week.