Ian Keatley, man-of-the-match when Munster beat Leinster 19-15 at Thomond Park in October. returns to the side to partner Murray at half-back.
Keatley will be looking to reach 500 points for the province, having scored 497 points in his 67 appearances to date.
Denis Hurley comes in to partner Casey Laulala in the centre with Laulala set to make his 47th appearance after less than two years at the province.
Simon Zebo is named on the left wing and will earn his 60th Munster cap with Keith Earls, who made a try-scoring return from injury against Treviso, and full-back Felix Jones retaining their places.
Props David Kilcoyne and BJ Botha are both drafted into the starting line-up to join hooker Damien Varley in the front row.
O'Connell, who missed the Treviso clash with a slight shoulder niggle, joins David Foley in the second row with captain O'Mahony coming into a back row that also includes O'Donnell and number 8 James Coughlan.
Duncan Casey, James Cronin and Alan Cotter are the front row replacements, while record caps holder Donncha O'Callaghan and CJ Stander complete the cover in the forwards.
Duncan Williams, JJ Hanrahan and Gerhard van den Heever are also named in the matchday squad and will be hoping to make an impact off the bench.
On the injury front, Donnacha Ryan is wearing a protective boot after a specialist identified a strain under his right foot. It is not a common injury and will need to be treated and monitored on a week-to-week basis.
Cotter is included on the bench after Stephen Archer pulled up in training yesterday, while fellow prop John Ryan is progressing well following return-to-play protocols after a concussion against Treviso.
MUNSTER (v Leinster): Felix Jones; Keith Earls, Casey Laulala, Denis Hurley, Simon Zebo; Ian Keatley, Conor Murray; David Kilcoyne, Damien Varley, BJ Botha, David Foley, Paul O'Connell, Peter O'Mahony (capt), Tommy O'Donnell, James Coughlan.
Replacements: Duncan Casey, James Cronin, Alan Cotter, Donncha O'Callaghan, CJ Stander, Duncan Williams, JJ Hanrahan, Gerhard van den Heever.