The Dragons, who beat the Ospreys on Tuesday to secure Heineken Cup qualification, are also in action again on Friday night when they host Magners League champions Leinster at Rodney Parade.
The last game on Friday sees Ulster host the Cardiff Blues. Victory would give the Welsh region runners-up spot in the league for the second year running, however they have lost on all five of their previous visits to Ravenhill.
Saturday sees both Scottish teams in action. Glasgow Warriors travel to Heineken Cup finalists Munster, while Edinburgh are in Llanelli to play Scarlets.
Both visiting teams are looking for their highest ever finish in the Magners League - victories would go some way to secure that.
For a review of round 17 of the Magners League, please click here.
MAGNERS LEAGUE - ROUND 18 FIXTURES:
Friday, May 9 -
Connacht v Ospreys, The Sportsground, 6.30pm
Newport Gwent Dragons v Leinster, Rodney Parade, 7.10pm (live BBC Wales/Setanta Sports Ireland)
Ulster v Cardiff Blues, Ravenhill, 7.30pm
Saturday, May 10 -
Munster v Glasgow Warriors, Musgrave Park, 5pm (live Setanta Sports Ireland)
Llanelli Scarlets v Edinburgh, Stradey Park, 5.30pm (live S4C)