In the pack there are starts for Cian Healy, Brian Blaney and Stephen Knoop, with Devin Toner lining up alongside Trevor Hogan in the second row.
Cameron Jowitt and Kevin McLaughlin both start in the back row alongside Stephen Keogh who moves to number eight.
Bernard Jackman, Malcolm O'Kelly and Chris Whitaker have all been named on a strong-looking replacements bench.
LEINSTER (v Newport Gwent Dragons): Girvan Dempsey; Shane Horgan, Brian O'Driscoll (capt), Michael Berne, Luke Fitzgerald; Jonathan Sexton, Chris Keane; Cian Healy, Brian Blaney, Stephen Knoop, Trevor Hogan, Devin Toner, Cameron Jowitt, Kevin McLaughlin, Stephen Keogh.
Replacements: Bernard Jackman, Ronan McCormack, Malcolm O'Kelly, Richie Leyden, Chris Whitaker, Christian Warner, Gary Brown.