Andrew Conway, who made a successful return from injury on Monday night, comes in on the left wing with David Kearney stationed on the right wing.
Brendan Macken will form a centre partnership with Eoin O'Malley, who will make his 42nd senior appearance for the province, and Isaac Boss links up with Ian Madigan at half-back.
Final decisions on the make-up of the back row, and also the replacement back row and replacement outside back slots will be made closer to kick-off.
LEINSTER (v Connacht): Isa Nacewa; David Kearney, Eoin O'Malley, Brendan Macken, Andrew Conway; Ian Madigan, Isaac Boss; Jack McGrath, Richardt Strauss, Jamie Hagan, Leo Cullen (capt), Damian Browne, Rhys Ruddock, Kevin McLaughlin/Shane Jennings, Leo Auva'a.
Replacements: Sean Cronin, Heinke van der Merwe, Nathan White, Devin Toner, Shane Jennings/Jordi Murphy, John Cooney, Noel Reid/Fionn Carr, Luke Fitzgerald.