With Fergus McFadden on international duty and Eoin O'Malley on the replacements bench, Brendan Macken will resume his centre partnership with recent debutants Colm O'Shea who started the 42-8 victory over Benetton Treviso two weeks ago.
At half-back, Ireland international Isaac Boss again partners Ian Madigan who is the league's second top try scorer this season with six touchdowns.
Meanwhile, there are six further changes in the forwards including a completely new front row of Heinke van der Merwe, Richardt Strauss and Nathan White.
Mullingar's Mark Flanagan is set to earn his sixth Leinster cap when he lines up alongside Damian Browne in the second row.
Shane Jennings leads the team from openside flanker and is joined in the back row by Dominic Ryan and Leo Auva'a, who both featured as second half replacements in last weekend's 16-13 home win over the Scarlets.
The fit-again Andrew Conway takes his place amongst a replacements bench which also includes the likes of O'Malley and Devin Toner.
LEINSTER (v Glasgow Warriors): Isa Nacewa; David Kearney, Brendan Macken, Colm O'Shea, Fionn Carr; Ian Madigan, Isaac Boss; Heinke van der Merwe, Richardt Strauss, Nathan White, Damian Browne, Mark Flanagan, Dominic Ryan, Shane Jennings (capt), Leo Auva'a.
Replacements: Aaron Dundon, Jack McGrath, Jamie Hagan, Devin Toner, Jordi Murphy, John Cooney, Eoin O'Malley, Andrew Conway.