Heinke van der Merwe and Stan Wright take their places in the front row, with Devin Toner starting in the second row alongside skipper Leo Cullen.
Isaac Boss will make his 25th appearance of the season and his 100th league appearance in all, spanning both his Ulster and Leinster careers. The Ireland-capped scrum half partners Jonathan Sexton at half-back.
The final make-up of Leinster's replacements bench will be announced closer to kick-off.
LEINSTER (v Ulster): Isa Nacewa; Shane Horgan, Eoin O'Malley, Fergus McFadden, Luke Fitzgerald; Jonathan Sexton, Isaac Boss; Heinke van der Merwe, Richardt Strauss, Stan Wright, Leo Cullen (capt), Devin Toner, Kevin McLaughlin, Shane Jennings, Jamie Heaslip.
Replacements: Jason Harris-Wright, Cian Healy, Mike Ross, Nathan Hines, Sean O'Brien/Dominic Ryan, Eoin Reddan, Ian Madigan, David Kearney.