South Africa were the first international side to visit the newly-built Aviva Stadium in November 2010, winning a closely-fought Test by 23-21.
The Springboks will again open the international rugby season when they travel to the northern Hemisphere under the guidance of their new head coach Heyneke Meyer.
Ireland also last took on Argentina that same November in sub zero temperatures, with Declan Kidney's men winning the game on a 29-9 scoreline.
In between these two full internationals, the O2 Ireland Wolfhounds will play Fiji at Thomond Park.
Broadcast and ticketing details for all three games will be announced in the coming weeks.
2012 GUINNESS SERIES FIXTURES:
Saturday, November 10
O2 IRELAND WOLFHOUNDS v Fiji
Saturday, November 17
IRELAND v Argentina
Saturday, November 24