In Division 1A, league leaders Lansdowne travel to Castle Avenue to face sixth-placed Clontarf, while over at Templeville Road the reigning champions St. Mary's College will be hoping to get their season back on track when they host Old Belvedere.
In Cork, Temple Hill should be thronged for one of the biggest games in club rugby in the city when Cork Constitution entertain Dolphin.
In Limerick, the action takes place at Dooradoyle and Thomond Park. Garryowen, in second place in the table, will host the struggling Shannon, who have just parted company with head coach Stephen Keogh.
Meanwhile, Young Munster return to Thomond Park having beaten Shannon there recently but this time they face UL Bohemians.
In Division 1B, the Friday Night Lights action takes place in Ballynahinch, Buccaneers, UCD and Belfast Harlequins.
The unbeaten 'Hinch face a Dungannon side that have only managed one win in their opening four games.
Over at Deramore Park, 'Quins play host to a Ballymena side that are still without a win to their name. The action at Dubarry Park will feature Buccaneers and Bruff, while UCD play host to bottom side Blackrock College.
In Division 2A there is a Galway special as Galwegians host Corinthians at Crowley Park with local bragging rights at stake.
So wrap up warm and get down to your local club this Friday night and enjoy some top class club rugby in the Ulster Bank League.