This week's squad is bolstered by the return of four of Munster's Emerging Ireland representatives - Billy Holland, Sean Dougall, Robin Copeland and Johne Murphy.
Both Copeland and Australian centre Andrew Smith will make their first appearances for the province on Friday night.
Stephen Archer features in his first matchday squad since sustaining a neck injury in March and he is joined by last weekend's replacements, John Ryan and Kevin O'Byrne, in the all new front row.
In the second row Holland starts next to captain Donncha O'Callaghan as Sean McCarthy moves to the replacements, and with Copeland starting at number 8, CJ Stander switches to blindside flanker with Dougall completing the back row.
Scrum half Cathal Sheridan starts this week in place of Duncan Williams, while newcomer Smith and full-back Murphy, who captained Emerging Ireland in June, are also included in the back-line.
Cian Bohane moves to inside centre with Smith making his first start for Munster in the number 13 jersey. Darren Sweetnam and Ronan O'Mahony retain their places on the wings.
Duncan Casey makes a timely return from his shoulder rehabilitation and is named on the extended list of replacements.
There are a limited number of tickets currently available to buy online here, from the Ticket Offices in Musgrave Park and Thomond Park, and from the Ticketmaster van outside the Cork Road entrance at the RSC on Friday - subject to availability.
MUNSTER (v London Irish): Johne Murphy; Ronan O'Mahony, Andrew Smith, Cian Bohane, Darren Sweetnam; Johnny Holland, Cathal Sheridan; John Ryan, Kevin O'Byrne, Stephen Archer, Donncha O'Callaghan (capt), Billy Holland, CJ Stander, Sean Dougall, Robin Copeland.
Replacements: Ger Slattery, Duncan Casey, Alan Cotter, BJ Botha, Sean McCarthy, John Madigan, Shane Buckley, Barry O'Mahony, Duncan Williams, David Johnston, Ivan Dineen, Rory Scannell.
The Ireland Under-18 and Under-19 squads had a busy Easter period with seven matches played in Ashbourne, Cardiff, Llanelli, Caerphilly and Bordeaux. Check out some of the tries scored. Full match reports are available on www.irishrugby.ie.
Speaking to RTE Radio rugby correspondent Michael Corcoran, Ireland head coach Joe Schmidt was asked about prioritising players playing in Ireland when it comes to national selection over those who are based overseas.
In an interview broadcast on RTE Radio 1's 'Sunday Sport' programme, Ireland head coach Joe Schmidt discussed the challenges and opportunities presented by the summer tour to the USA and Japan, and also looked ahead to next month's Rugby World Cup Pool Draw.
Speaking about working with the provinces and monitoring players' progress, Ireland head coach Joe Schmidt told RTE Radio 1: "For us, having the best quality of performance within the provinces, getting some really good coaching from the provincial coaches, which we know is happening at the moment, that's the foundation that we need because in the end we get the players in a match week pretty much."
In an interview with RTE Radio rugby correspondent Michael Corcoran, Ireland head coach Joe Schmidt confirmed that Girvan Dempsey, Felix Jones and Ronan O'Gara will be incorporated into the coaching group for the upcoming summer tour to the USA and Japan.
IRFU National Talent Development Manager Hendrik Kruger says the Easter age-grade internationals give the Ireland Under-18 and Under-19 players 'the chance to represent their country and experience international rugby' and are 'the highlight of their season'.
The Ireland Under-18 Clubs & Schools team (sponsored by PwC) played the England U-18 Counties side in the first of two matches at Ashbourne RFC this week. Check out the highlights from Wednesday's entertaining clash.
Four of our stadiums through the eyes of four Irish sporting legends. O'Driscoll on Aviva Stadium, Brogan on Croke Park, Matthews on Kingspan Stadium and O'Connell on Thomond Park. The world is invited #Ireland2023.
Irish Rugby TV caught up with flanker Sean O'Brien to get his reaction following Ireland's hard-earned 13-9 victory over RBS 6 Nations champions England. He singled out man-of-the-match Peter O'Mahony for special praise.
Peter O'Mahony reflects on what went wrong for Ireland in Cardiff and tells Irish Rugby TV that he is focusing on the squad and their work this week ahead of the final Six Nations game against England.
The Ireland squad paid a visit to Monaghan last week and held an open training session in Monaghan RFC. We spoke to Andrew Trimble after the session which was attended by over 2,000 cheering supporters.