The Munster team to face Edinburgh in Saturday's RaboDirect PRO12 encounter at Meggetland (kick-off 5pm) shows 11 changes to the side that started against Toulon last weekend.
After the Ospreys' defeat to Zebre last night Munster are now guaranteed a RaboDirect PRO12 semi-final place along with Leinster and Glasgow Warriors.
But Rob Penney's men will continue to battle for home advantage in the play-offs with the Edinburgh challenge up first this weekend.
A new-look front row sees James Cronin and John Ryan pack down either side of hooker Duncan Casey. Having featured last weekend against Toulon, Cronin makes his first start for the province since the Benetton Treviso game in March.
The familiar duo of Paul O'Connell and Donncha O'Callaghan combine in the second row, while Tommy O'Donnell and Paddy Butler return to the back row alongside blindside flanker CJ Stander.
Last time out in the league Butler impressed with a man-of-the-match performance against Connacht, securing the bonus point try at the Sportsground.
After an excellent rehab on a groin injury, JJ Hanrahan suffered no ill-effects from the last 20 minutes of the Heineken Cup semi-final in Marseille and starts alongside Conor Murray in the half-backs.
Denis Hurley and Johne Murphy, both of whom signed new contracts with Munster this week, form the centre partnership. Meanwhile, Simon Zebo switches to full-back with Andrew Conway and Gerhard van den Heever introduced on the wings.
The province take a strong bench to Scotland that includes five of last weekend's starting team, and Luke O'Dea is named in his first senior squad of the season after overcoming a string of injuries.
MUNSTER (v Edinburgh): Simon Zebo, Gerhard van den Heever, Johne Murphy, Denis Hurley, Andrew Conway; JJ Hanrahan, Conor Murray; James Cronin, Duncan Casey, John Ryan, Donncha O'Callaghan, Paul O'Connell (capt), CJ Stander, Tommy O'Donnell, Paddy Butler.
Replacements: Damien Varley, David Kilcoyne, Alan Cotter, David Foley, James Coughlan, Duncan Williams, Ian Keatley, Luke O'Dea.
Looking forward to facing England on Sunday, Ireland winger Tommy Bowe said: "We've trained very well this week, we're really excited about the game. It's about going out there and doing whatever we can to get ourselves that win."
Second row Devin Toner previews Ireland's crunch RBS 6 Nations clash with England, saying: "It's a pretty formidable English pack. Attwood and Kruis have played fantastically well. They're well drilled and focused and their scrum and lineout are very good."
Looking forward to facing England this weekend, Ireland back rower Sean O'Brien said: "It's obviously exciting, but it's one game at a time. I don't think there's any more pressure on us than in the first two games. That's the way you have to look at it."
Irish Rugby TV sat down with Ireland Under-20 scrum coach John Fogarty to talk about the U-20 Six Nations so far and Friday's clash with England at Donnybrook. Tickets are on sale on www.ticketmaster.ie.
Ireland Under-20 captain Nick McCarthy and fellow back Billy Dardis spoke to Irish Rugby TV about Friday's U-20 Six Nations showdown with England at Donnybrook. Tickets available on www.ticketmaster.ie.
Shane Byrne and Malcolm O'Kelly preview the Ireland v England Legends match which takes place at Donnybrook this coming Saturday (kick-off 7.30pm). Tickets are available from www.ticketmaster.ie. All proceeds from the game will go to support the IRFU Charitable Trust and the RFU All Schools Charity.
Watch highlights from the Ireland team announcement press conference as Joe Schmidt reveals the team to play France. Peter O'Mahony says it is good to 'have some big figures back' for Saturday's clash.
Ireland Under-20 centre Garry Ringrose said the squad were 'delighted' to run in seven tries away to Italy. He also previews the French match and talks about his involvement in a previous Ireland senior training camp.