The Munster team to face Edinburgh in Saturday's RaboDirect PRO12 encounter at Meggetland (kick-off 5pm) shows 11 changes to the side that started against Toulon last weekend.
After the Ospreys' defeat to Zebre last night Munster are now guaranteed a RaboDirect PRO12 semi-final place along with Leinster and Glasgow Warriors.
But Rob Penney's men will continue to battle for home advantage in the play-offs with the Edinburgh challenge up first this weekend.
A new-look front row sees James Cronin and John Ryan pack down either side of hooker Duncan Casey. Having featured last weekend against Toulon, Cronin makes his first start for the province since the Benetton Treviso game in March.
The familiar duo of Paul O'Connell and Donncha O'Callaghan combine in the second row, while Tommy O'Donnell and Paddy Butler return to the back row alongside blindside flanker CJ Stander.
Last time out in the league Butler impressed with a man-of-the-match performance against Connacht, securing the bonus point try at the Sportsground.
After an excellent rehab on a groin injury, JJ Hanrahan suffered no ill-effects from the last 20 minutes of the Heineken Cup semi-final in Marseille and starts alongside Conor Murray in the half-backs.
Denis Hurley and Johne Murphy, both of whom signed new contracts with Munster this week, form the centre partnership. Meanwhile, Simon Zebo switches to full-back with Andrew Conway and Gerhard van den Heever introduced on the wings.
The province take a strong bench to Scotland that includes five of last weekend's starting team, and Luke O'Dea is named in his first senior squad of the season after overcoming a string of injuries.
MUNSTER (v Edinburgh): Simon Zebo, Gerhard van den Heever, Johne Murphy, Denis Hurley, Andrew Conway; JJ Hanrahan, Conor Murray; James Cronin, Duncan Casey, John Ryan, Donncha O'Callaghan, Paul O'Connell (capt), CJ Stander, Tommy O'Donnell, Paddy Butler.
Replacements: Damien Varley, David Kilcoyne, Alan Cotter, David Foley, James Coughlan, Duncan Williams, Ian Keatley, Luke O'Dea.
Head coach Nigel Carolan talks about the squad selection for next month's World Rugby Under-20 Championship in Manchester, while captain James Ryan is looking forward to leading the side against pool rivals Wales, New Zealand and Georgia.
Ireland Women's captain Niamh Briggs spoke about her excitement for the Women's Rugby World Cup as the official tournament logo was unveiled in UCD today. She is also looking forward to facing England, Canada and New Zealand in November this year as part of the build-up to #WRWC2017.
Ireland Women's Sevens captain Lucy Mulhall is in Langford this week for the Canada leg of the HSBC World Rugby Women's Sevens Series. Following Ireland's Bowl win in Atlanta, Lucy previews our prospects this weekend.
Ireland Women's Sevens captain Lucy Mulhall speaks about the build-up to the HSBC World Rugby Women's Sevens tournament in Atlanta, Georgia. The girls in green begin the pool stages against France at 12.52pm local time/5.52pm Irish time today.
IRFU High Performance Manager Colin McEntee reflects on the Easter matches played by the Ireland Under-18 and Under-19 teams, which ended last weekend with wins over the England Counties U-18s and France U-19s.
Watch highlights of the Ireland Under-18s' seven-try 43-0 victory over Scotland during the inaugural U-18 Five Nations Festival in Caerphilly, Wales. Number 8 and captain Caelan Doris scored a hat-trick of tries and winger Daniel Hurley bagged a brace.
Railway Union's Kim Flood made her debut at full-back for the Ireland Women in last weekend's 14-3 Six Nations win over Italy. She is looking forward to experiencing the partisan crowd at Donnybrook again this Sunday when Scotland are the visitors. Tickets are available from Ticketmaster.ie.
Ireland scrum coach Greg Feek spoke to Irish Rugby TV on the eve of the final round of the RBS 6 Nations Championship. He is happy that the team are focused but warns that it will be a tough encounter with Scotland tomorrow.
Looking forward to the lineout battle with Scotland, Ireland lock Devin Toner said: "We went well again Italy, I think our set piece went well. If we can just build on that and build on the positives then I think we'll be okay."