The Munster team to face Edinburgh in Saturday's RaboDirect PRO12 encounter at Meggetland (kick-off 5pm) shows 11 changes to the side that started against Toulon last weekend.
After the Ospreys' defeat to Zebre last night Munster are now guaranteed a RaboDirect PRO12 semi-final place along with Leinster and Glasgow Warriors.
But Rob Penney's men will continue to battle for home advantage in the play-offs with the Edinburgh challenge up first this weekend.
A new-look front row sees James Cronin and John Ryan pack down either side of hooker Duncan Casey. Having featured last weekend against Toulon, Cronin makes his first start for the province since the Benetton Treviso game in March.
The familiar duo of Paul O'Connell and Donncha O'Callaghan combine in the second row, while Tommy O'Donnell and Paddy Butler return to the back row alongside blindside flanker CJ Stander.
Last time out in the league Butler impressed with a man-of-the-match performance against Connacht, securing the bonus point try at the Sportsground.
After an excellent rehab on a groin injury, JJ Hanrahan suffered no ill-effects from the last 20 minutes of the Heineken Cup semi-final in Marseille and starts alongside Conor Murray in the half-backs.
Denis Hurley and Johne Murphy, both of whom signed new contracts with Munster this week, form the centre partnership. Meanwhile, Simon Zebo switches to full-back with Andrew Conway and Gerhard van den Heever introduced on the wings.
The province take a strong bench to Scotland that includes five of last weekend's starting team, and Luke O'Dea is named in his first senior squad of the season after overcoming a string of injuries.
MUNSTER (v Edinburgh): Simon Zebo, Gerhard van den Heever, Johne Murphy, Denis Hurley, Andrew Conway; JJ Hanrahan, Conor Murray; James Cronin, Duncan Casey, John Ryan, Donncha O'Callaghan, Paul O'Connell (capt), CJ Stander, Tommy O'Donnell, Paddy Butler.
Replacements: Damien Varley, David Kilcoyne, Alan Cotter, David Foley, James Coughlan, Duncan Williams, Ian Keatley, Luke O'Dea.
Irish Rugby TV went behind the scenes at the launch of the RBS 6 Nations in the Hurlingham Club in London. It was a case of 'lights, camera, action' as Joe Schmidt and Paul O'Connell spoke to the assembled media to preview rugby's greatest Championship.
Ulster youngster Iain Henderson talks about his return from injury after seven months on the sidelines. He will play for Ireland Wolfhounds on Friday, as competition increases for Six Nations selection.
Ireland head coach Joe Schmidt speaks about player injuries ahead of the start of the RBS 6 Nations, his side's title defence, the challenge of facing Italy away first up and mentions some of the players who might feature for the Ireland Wolfhounds on Friday.
Newly-appointed Ireland Women's captain Niamh Briggs chats to Russell Hargreaves at the launch of the RBS 6 Nations Championship. She talks about her captaincy role, the uncapped players who have come on board and the mood in camp ahead of next week's opener away to Italy.
Speaking at the 2015 RBS 6 Nations launch, Ireland captain Paul O'Connell comments on matters both provincial and national as he looks forward to leading his country for the defence of their Championship crown.
Ireland Under-20 head coach Nigel Carolan looks forward to the 2015 campaign and discusses the objectives for his squad this season. There is a strong emphasis on player development at this level which Carolan believes is important in bringing young talent through to the professional game.
Speaking ahead of Saturday's clash with Australia, Ireland flanker Rhys Ruddock said: "We need to bring the defensive physicality we had against South Africa, as Australia have threats all over the park. We need to be at the top of our game."
As the countdown continues to Ireland's GUINNESS Series showdown with Australia, number 8 Jamie Heaslip talks about the Georgia game and what it will be like to face an 'old friend' in Michael Cheika this Saturday.