The Munster team to face Edinburgh in Saturday's RaboDirect PRO12 encounter at Meggetland (kick-off 5pm) shows 11 changes to the side that started against Toulon last weekend.
After the Ospreys' defeat to Zebre last night Munster are now guaranteed a RaboDirect PRO12 semi-final place along with Leinster and Glasgow Warriors.
But Rob Penney's men will continue to battle for home advantage in the play-offs with the Edinburgh challenge up first this weekend.
A new-look front row sees James Cronin and John Ryan pack down either side of hooker Duncan Casey. Having featured last weekend against Toulon, Cronin makes his first start for the province since the Benetton Treviso game in March.
The familiar duo of Paul O'Connell and Donncha O'Callaghan combine in the second row, while Tommy O'Donnell and Paddy Butler return to the back row alongside blindside flanker CJ Stander.
Last time out in the league Butler impressed with a man-of-the-match performance against Connacht, securing the bonus point try at the Sportsground.
After an excellent rehab on a groin injury, JJ Hanrahan suffered no ill-effects from the last 20 minutes of the Heineken Cup semi-final in Marseille and starts alongside Conor Murray in the half-backs.
Denis Hurley and Johne Murphy, both of whom signed new contracts with Munster this week, form the centre partnership. Meanwhile, Simon Zebo switches to full-back with Andrew Conway and Gerhard van den Heever introduced on the wings.
The province take a strong bench to Scotland that includes five of last weekend's starting team, and Luke O'Dea is named in his first senior squad of the season after overcoming a string of injuries.
MUNSTER (v Edinburgh): Simon Zebo, Gerhard van den Heever, Johne Murphy, Denis Hurley, Andrew Conway; JJ Hanrahan, Conor Murray; James Cronin, Duncan Casey, John Ryan, Donncha O'Callaghan, Paul O'Connell (capt), CJ Stander, Tommy O'Donnell, Paddy Butler.
Replacements: Damien Varley, David Kilcoyne, Alan Cotter, David Foley, James Coughlan, Duncan Williams, Ian Keatley, Luke O'Dea.
Speaking after the 3rd/4th place play-off defeat to France, Ireland Women's head coach Philip Doyle said: "Semi-final of a World Cup, ranked fourth - I'm absolutely thrilled with that. It's one step, we've learned a huge amount at this World Cup. We'll put it in the bank now and hopefully, in three years' time at the next World Cup, another Irish team will be there (competing in the last-four)."
The Ireland squad got their first taste of the new Canterbury training kit with new sponsor Three on board. Check out the gear as Cian Healy, Tommy Bowe and Devin Toner give us their thoughts and register for updates on shop.irishrugby.ie.
Speaking ahead of the Women's World Cup semi-final against England, Ireland head coach Philip Doyle said: "We're really looking forward to it, it's going to be a great occasion. I'm sure it will be like any another massive game in that it's all down to percentages."
Relive all the drama and excitement of the Ireland Women's historic victory over New Zealand with Wyn Gruffydd's memorable commentary, the roar of the Irish fans in Marcoussis and Fiona Coghlan's inspiring post-match interview.
Taoiseach Enda Kenny has joined a host of political, sporting and broadcasting legends to send a message of support to the Ireland Women's squad ahead of the forthcoming Women's Rugby World Cup, which begins in Paris next Friday.
Speaking after the IRFU's Annual Council meeting, Chief Executive Philip Browne highlighted the importance of ticket revenue to the Union and also their sustained investments in the professional and domestic games.