One of Munster's most consistent and experienced performers, 'Micko' retired at the end of the 2011/12 season after making 207 Munster appearances over a 14-year period.
The Corkman began his playing career in August 1998 and made his Heineken Cup debut against Neath at Musgrave Park in September of that year.
On retirement, the long-serving second row pursued a number of successful business opportunities, including Home Instead Senior Care, while also remaining in the rugby environment with coaching spells with Pres Cork and Cork Constitution.
Commenting on his new appointment, O'Driscoll said: "I am really looking forward to working with Anthony, Niall (O'Donovan) and the team again.
"I was immersed in the Munster way for over a decade, playing at the top level in Ireland and France, and I believe I can call on that wealth of experience in this new role."