There is quite a line-up of talented backs who would relish the chance to fill O'Driscoll's boots, among them Connacht's Robbie Henshaw who only turns 21 in mid-June.
Henshaw was on the fringes of the Ireland squad throughout their successful Six Nations campaign, further familiarising himself with Joe Schmidt's coaching regime and training away in diligent fashion at Carton House.
Schmidt spoke recently of O'Driscoll's behind-the-scenes work with both Henshaw and Darren Cave, two players who have been earmarked as immediate options in the number 13 shirt.
The Argentinian tour comes a year on from Henshaw's Ireland debut against the USA - his first and only start to date - and it is clear that he has since soaked up as much information as possible from the departing O'Driscoll.
"He has taken one-to-one analysis sessions with me and he has had one-to-one meetings with me on what he's seen me do and the things I can work on. It's really one-to-one coaching, which was great for me," Henshaw told the Irish Independent of his time with O'Driscoll in camp.
"It's a great boost of confidence when he tells you what your assets are and what you can be working on - even just being around camp and watching him play and playing against him in the opposite team during the week, you pick up lots of things."
A tall and increasingly powerful presence who is now tipping the scales at 100kg, Henshaw is evidently a quick learner when you look at the milestones he has ticked off so far in his career.
A Connacht senior debut in September 2012, a first Heineken Cup cap the following month, his debut for the O2 Ireland Wolfhounds in January 2013 and two weeks later a winning debut with the Ireland Under-20s in his native Athlone.
Ireland senior honours followed in June of that year and an appearance off the bench against Australia last November took his Test caps tally to three at the tender age of 20.
O'Driscoll rates the exciting Connacht star highly, remarking recently that he is 'a very, very talented young lad' who has 'all the attributes to be a seasoned campaigner for Ireland for many, many years'.
It is clear from how Henshaw talks about Ireland's record caps holder and top try scorer that there is mutual admiration there.
"Brian has spoken great words about me and I'm delighted that he has looked at me as a future 13. But I have to just focus on playing more in the position, playing well in the position, and learning.
"I learned a lot up in camp with him, it was invaluable the experience I got off him, just focusing on developing more as a 13."
Given the strong centre partnership struck up between Eoin Griffin and David McSharry, Henshaw has played most of his rugby for Connacht at full-back.
It is a position he is very comfortable in, but many feel his future lies at outside centre - certainly he has the running game, the physicality and distribution skills to settle there.
His flashes of brilliance this season include the strong run and classy one-handed offload in the lead up to Kieran Marmion's try against Toulouse, and the surge over halfway - past both Dave Kearney and Gordon D'Arcy - and long pass for Fionn Carr to score against Leinster.
Whatever the future holds for Henshaw, he is certainly enjoying his rugby at the moment and being a fixture in Ireland's training squad during the Six Nations and witnessing the Paris celebrations firsthand has made him hungry for more.
"I think I was in a great position to be involved (with Ireland) in some way or another. I think if there was any injury crisis I would have been brought in (to play)," he admitted.
"I wasn't too far away. I was just thrilled to be among the group and learned loads.
"Being in that dressing room after the win against France, it was a feeling that I'll never forget. It just opened my eyes to how rare it is that a team can win a Six Nations.
"Brian O'Driscoll has only won two in his career, so it was just amazing to be a part of it and just looking forward to hopefully going on in the future and doing the same again."
He compared Ireland head coach Schmidt to a teacher when asked about what it is like to work with him, something he hopes to do again in sunnier climes in Argentina.
"The attention to detail was unbelievable, the guys were coming out of the camp knowing everything about everyone and knowing every role in their position," he explained.
"It was great and it just showed the attention to detail and how we won the Six Nations up there (at Carton House).
"Joe is like the teacher and you're the student. It's like you're studying rugby full-time up there, it was unbelievable and it was great to see the hard work pay off in the end."
Commenting on the summer tour, Henshaw added: "It's going to be huge for Joe and the team. He'll have a good idea of what players he can have a look at over there and what players he can bring into next year's Six Nations and the World Cup, so please God I'll get on the plane and I'll get a look in."