Scrum half Ben Youngs is promoted from the bench to replace Mike Phillips. He joins brother Tom, who plays his second Test at hooker, while flanker Dan Lydiate, who captained the Lions against the Rebels on Tuesday night, replaces Tom Croft and Tommy Bowe takes over from Alex Cuthbert on the right wing following his return to full fitness.
Two additional changes are forced by injury. Second row Geoff Parling replaces Paul O'Connell, who suffered a fracture to his right arm in the first Test. Mako Vunipola also comes into the front row for Alex Corbisiero, who strained a calf muscle in the same game.
On the bench there are five changes with Ryan Grant, Sean O'Brien, Conor Murray, Croft and Cuthbert earning spots alongside Richard Hibbard, Dan Cole and Owen Farrell.
Lions tour manager Andy Irvine said: "We are one Test-to-nil up and have a wonderful chance to win our first series since 1997. Sixteen years is a long time to wait for a series win. We were very close in 2009 and the whole squad is firmly focused on victory this weekend.
"The Wallabies are always a tough proposition at home and showed in 2001, after losing the first Test, that they are capable of coming from behind in a series. We will not underestimate them and will be prepared."
Head coach Warren Gatland added: "We said after the first Test that we had improvement in us and we are confident that this is the case. Several players have put their hands up this week and have forced their way into the Test side while several players have returned to fitness.
"That is typical of Lions tours. We want players to constantly push for selection, we then select who is on form and who is available. Based on that we have selected a squad that is capable of winning the Test and securing the series."
BRITISH & IRISH LIONS Team & Replacements (v Australia, 2013 British & Irish Lions Tour Second Test, Etihad Stadium, Melbourne, Saturday, June 29, kick-off 8.05pm local time/11.05am Irish time):
15. Leigh Halfpenny (Cardiff Blues/Wales)
14. Tommy Bowe (Ulster/Ireland)
13. Brian O'Driscoll (Leinster/Ireland)
12. Jonathan Davies (Scarlets/Wales)
11. George North (Scarlets/Wales)
10. Jonathan Sexton (Leinster/Ireland)
9. Ben Youngs (Leicester Tigers/England)
2. Tom Youngs (Leicester Tigers/England)
3. Adam Jones (Ospreys/Wales)
4. Alun Wyn Jones (Ospreys/Wales)
5. Geoff Parling (Leicester Tigers/England)
6. Dan Lydiate (Newport Gwent Dragons/Wales)
7. Sam Warburton (Cardiff Blues/Wales) (capt)
8. Jamie Heaslip (Leinster/Ireland)
16. Richard Hibbard (Ospreys/Wales)
17. Ryan Grant (Glasgow Warriors/Scotland)
18. Dan Cole (Leicester Tigers/England)
19. Tom Croft (Leicester Tigers/England)
20. Sean O'Brien (Leinster/Ireland)
21. Conor Murray (Munster/Ireland)
22. Owen Farrell (Saracens/England)
23. Alex Cuthbert (Cardiff Blues/Wales)
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