Nine players who started that night are either injured or involved with the Ireland squad, while three more - forwards Mike Sherry, David Foley and Tommy O'Donnell - are named on the province's bench.
There are first starts of the season for Danny Barnes and Ivan Dineen in the back-line, while centre JJ Hanrahan, winger Johne Murphy and lock Ian Nagle all get their second starts of the campaign.
The South African has featured in recent British & Irish Cup games and came on as a replacement in January against the Blues. He is picked at blindside flanker in a back row completed by Sean Dougall and stand-in captain James Coughlan.
MUNSTER (v Edinburgh): Denis Hurley; Johne Murphy, Ivan Dineen, JJ Hanrahan, Danny Barnes; Ian Keatley, Duncan Williams; Marcus Horan, Damien Varley, BJ Botha, Ian Nagle, Billy Holland, CJ Stander, Sean Dougall, James Coughlan (capt).
Replacements: Mike Sherry, Wian du Preez, John Ryan, David Foley, Tommy O'Donnell, Paddy Butler, Cathal Sheridan, Scott Deasy.