It is a case of youth and experience in the centre where Leinster's most-capped player Gordon D'Arcy, who is set to make his 226th appearance, will partner 22-year-old European debutant Brendan Macken.
David Kearney and Fergus McFadden will be joined in a strong back-three by Rob Kearney, who is set for his 135th outing in Leinster colours.
The pack is unchanged from the one that started against Munster last weekend with Jamie Heaslip once more leading the team. The number 8 will be flanked in the back row by Kevin McLaughlin and Sean O'Brien.
Cian Healy will again partner fellow Ireland internationals Sean Cronin and Mike Ross in the front row, with Devin Toner locking down alongside Mike McCarthy.
Incidentally, Ireland duo McLaughlin and McFadden will be making their 99 career appearances for their home province in Swansea.
LEINSTER (v Ospreys): Rob Kearney; Fergus McFadden, Brendan Macken, Gordon D'Arcy, David Kearney; Jimmy Gopperth, Isaac Boss; Cian Healy, Sean Cronin, Mike Ross, Devin Toner, Mike McCarthy, Kevin McLaughlin, Sean O'Brien, Jamie Heaslip (capt).
Replacements: Aaron Dundon, Jack McGrath, Martin Moore, Quinn Roux, Rhys Ruddock, Eoin Reddan, Ian Madigan, Luke Fitzgerald.