Jared Payne switches to full-back in place of Craig Gilroy, who has failed to recover from the ankle injury that he picked up against the Ospreys, with Darren Cave coming in at outside centre
In the only change up front, Roger Wilson starts at blindside flanker with Robbie Diack dropping down to the replacements bench.
Ruan Pienaar, who signed a new three-year contract extension with the province this week, is also named among the replacements.
John Afoa was unavailable for selection but is recovering well from injury. The game will be shown live on Sky Sports 1, with coverage starting at 7pm.
ULSTER (v Leicester Tigers): Jared Payne; Andrew Trimble, Darren Cave, Luke Marshall, Tommy Bowe; Paddy Jackson, Paul Marshall; Tom Court, Rory Best, Declan Fitzpatrick, Johann Muller (capt), Dan Tuohy, Roger Wilson, Chris Henry, Nick Williams.
Replacements: Rob Herring, Callum Black, Ricky Lutton, Iain Henderson, Robbie Diack, Ruan Pienaar, Stuart Olding, Michael Allen.