Former Ireland Under-20 international Paddy Jackson will partner Murray at half-back with his Ulster colleagues Luke Marshall and Darren Cave forming the centre partnership outside him.
The back-three comprises of the uncapped Craig Gilroy on the left wing with Fergus McFadden on the right and Denis Hurley at full-back.
David Kilcoyne, who won his first cap last weekend, will pack down alongside Sean Cronin and Ross in the front row, while Dan Tuohy and the 89-times capped Donncha O'Callaghan will link up in the second row.
Heaslip anchors the scrum with Iain Henderson, a debutant as a replacement against the Springboks, and John Muldoon taking the blindside and openside flanker berths respectively.
There will be Park & Ride facilities in operation for the Ireland XV v Fiji match on Saturday, at the following locations:
- Kilmurry Lodge Hotel, starting from 2.30pm
- Radisson Hotel, Ennis Road, starting from 3.30pm
- South Court Hotel, Raheen, starting from 3.30pm
- Woodlands Hotel, Adare, starting at 4.30pm
There will also be a Public Bus Service running from Henry Street in Limerick city centre, starting at 3.30pm.
IRELAND XV Team & Replacements (v Fiji, 2012 GUINNESS Series, Thomond Park, Saturday, November 17, kick-off 5.30pm):
15 - Denis Hurley (Dolphin/Munster/1 cap)
16 - Richardt Strauss (Old Wesley/Leinster/1)
17 - Cian Healy (Clontarf/Leinster/34)
18 - Michael Bent (Leinster/1)
19 - Donnacha Ryan (Shannon/Munster/23)
20 - Chris Henry (Malone/Ulster/3)
21 - Paul Marshall (Belfast Harlequins/Ulster) *
22 - Jonathan Sexton (St. Mary's College/Leinster/33)
23 - Simon Zebo (Cork Constitution/Munster/2)
* Denotes uncapped player