Tommy Bowe, who played 20 minutes against Saracens in last Saturday's Heineken Cup quarter-final defeat, is in line to make his first start for Ulster since he suffered knee ligament damage against Northampton Saints in December.
His fellow Ireland internationals, Andrew Trimble and Paddy Jackson, are not included as they are rested for the game.
Ulster are second in the RaboDirect PRO12, one point behind leaders Glasgow Warriors and three points ahead of third-placed Leinster.
Tickets for the match are still available and they can be purchased here.
ULSTER Squad (v Newport Gwent Dragons) - Backs (11): Ruan Pienaar, Jared Payne, Craig Gilroy, Paul Marshall, Peter Nelson, Tommy Bowe, Niall O'Connor, Michael Allen, Adam D'Arcy, Stuart Olding, Darren Cave.
Forwards (14): Mike McComish, Callum Black, Rory Best, Robbie Diack, Dan Tuohy, Lewis Stevenson, Declan Fitzpatrick, Nick Williams, Rob Herring, Ali Birch, Ricky Lutton, Tom Court, Iain Henderson, Neil McComb.