With their interest in the RaboDirect PRO12 understandably superceded by involvement in the Heineken Cup semi-final, the province's head coach Rob Penney has rested most of his frontliners.
Academy player Ronan O'Mahony will make his league debut on Friday night, while his Academy colleague Cian Bohane, named among the replacements, is also in line for his first Munster senior cap.
Marcus Horan, Munster's most-capped forward who recently confirmed he will retire at the end of the season, is included on the bench.
MUNSTER (v Newport Gwent Dragons): Denis Hurley; Ronan O'Mahony, Ivan Dineen, JJ Hanrahan, Johne Murphy; Ian Keatley, Cathal Sheridan; Wian du Preez, Damien Varley, Stephen Archer, David Foley, Billy Holland, David O'Callaghan, Niall Ronan, Paddy Butler.
Replacements: Sean Henry, Marcus Horan, John Ryan, Ian Nagle, CJ Stander, Duncan Williams, Cian Bohane, Danny Barnes.