Gordon D'Arcy partners Brendan Macken in the centre, with Eoin Reddan set to make his 74th Leinster appearance at half-back where he will link up with the versatile Ian Madigan.
Kevin McLaughlin returns to the back row alongside fellow Ireland internationals Jamie Heaslip and Sean O'Brien.
Meanwhile, tighthead prop Michael Bent will make his second start for the province after being named alongside hooker Sean Cronin and Cian Healy in the front row.
Former CBS Naas back Adam Byrne has been named on the bench. He is in line to make his senior bow after impressing with two tries for the Leinster 'A' side in last weekend's British & Irish Cup victory over Jersey.
LEINSTER (v Ulster): Noel Reid; Andrew Conway, Brendan Macken, Gordon D'Arcy, Fergus McFadden; Ian Madigan, Eoin Reddan; Cian Healy, Sean Cronin, Michael Bent, Leo Cullen (capt), Devin Toner, Kevin McLaughlin, Sean O'Brien, Jamie Heaslip.
Replacements: Aaron Dundon, Heinke van der Merwe, Jamie Hagan, Tom Denton, Rhys Ruddock, Isaac Boss, Andrew Goodman, Adam Byrne.