Argentina star Felipe Contepomi will make his first start of the season and partners Christian Warner at centre, while summer signings Guy Easterby (scrum-half) and Ricky Nebbett (prop) - second half substitutes in Leinster's 17-15 win over Munster last weekend - will make their first starts for the province.
Denis Hickie starts at full-back in an attacking back-three alongside last Saturday's try-scorers James Norton and Gary Brown. Easterby will partner Brian O'Meara - who boasts a 100% kicking ratio so far this season - at half-back. John McWeeney misses out with a hamstring strain sustained last weekend.
In the pack, Victor Costello starts at number eight with Des Dillon partnering skipper Leo Cullen in the second row. Eric Miller and Ciaran Potts both start at wing-forward.
David Blaney replaces Gavin Hickie at hooker with Nebbett taking Peter Coyle's place in the front row. Ireland international hooker Shane Byrne takes his place amongst the substitutes.
Declan Kidney has left two vacancies on the bench which will be confirmed closer to kick off.Leinster:15: Denis Hickie14: James Norton13: Christian Warner12: Felipe Contepomi11: Gary Brown10: Brian O'Meara9: Guy Easterby1: Ricky Nebbett2: David Blaney