This will be Jacobsen's first start in a Six Nations match but Hogg played in the 23-10 defeat game Wales last month and came on as a 60th minute replacement for Mather in Murrayfield last time out against England.
Coach Williams has no fears whatsover about the changes, " Allan Jacobsen is a very fine player, a good ball player and I believe he will do his country proud."proud,"
"Cameron (Mather) and Tom (Smith) are continuing to have treatment for their injuries, they're just not quite for this match but we're hopeful that they'll be back to us later in the tournament."
Jon Petrie comes onto the bench ahead of Simon Cross and Scott Gray, and Derrick Lee is promoted to the 22.
Scotland: Ben Hinshelwood (Worcester); Simon Danielli(Bath), Tom Philip (Edinburgh), Brendan Laney (Edinburgh), Simon Webster(Edinburgh); Chris Paterson capt (Edinburgh) , Chris Cusiter (Borders); SimonTaylor (Edinburgh), Jason White (Sale), Allister Hogg (Edinburgh), StuartGrimes (Newcastle), Scott Murray (Edinburgh), Bruce Douglas (Borders),Gordon Bulloch (Glasgow), Allan Jacobsen (Edinburgh).
Italy: Andrea Masi; Gonzalo Canale, Cristian Stoica,Manuel Dallan, Denis Dallan; Roland De Marigny, Paul Griffen; SergioParisse, Aaron Persico, Andrea De Rossi capt; Marco Bortolami, Santiago Dellape;Martin Castrogiovanni, Fabio Ongaro, Andrea Lo Cicero Replacements: Carlo Festuccia, Salvatore Perugini, CarloChecchinato, Silvio Orlando, Simon Picone, Rima Wakarua, Nicola Mazzucato Referee: Nigel Whitehouse (Wales)