He will be replaced by Wayne Julies, an inexperienced player at international level who won his last cap against Spain in the 1999 World Cup.
De Wet Barry's partnership with Stormers teammate Marius Joubert was expected to be one of the strong areas in a seriously untried Springboks side. They include three new caps plus the return of prop Os Du Randt who hasn't featured at international level for five years.
Ireland coach Eddie O'Sullivan however, will be dealing from a full pack with all those who were carrying slight injury able to take a full part in training yesterday. He is expected to name his side later today.
The Springboks team is: 15 Gaffie du Toit14 Breyton Paulse13 Marius Joubert12 Wayne Julies11 Henno Mentz10 Jaco van der Westhuyzen9 Fourie du Preez8 Pedrie Wannenburg7 Juan Smith6 Schalk Burger