The Irish will be captained again by Brian O'Driscoll who was recalled to the squad to replace the injured John Kelly and there is a return to the side from injury for Geordan Murphy and Kieron Dawson with Dawson's London Irish colleague Justin Bishop selected on the left wing.
David Humphreys and Guy Easterby form an all new half-back partnership, while Munster provide five of the pack including Horan who will be starting for the first time.
Newcomers onto the bench include Mick O'Driscoll and Gordon D'Arcy as well as Eric Miller, a player who has had his opportunities of international caps limited by injury.
Ireland. G Murphy; S Horgan, B O'Driscoll capt, K Maggs, J Bishop; D Humphreys, G Easterby; M Horan, F Sheahan, J Hayes; L Cullen. M O'Kelly; A Quinlan, K Dawson, A Foley.