When these teams met at the Millennium Stadium last year, it was a hard-fought encounter that eventually went Ireland's way on a 17-15 scoreline as the men in green clinched a thrilling Grand Slam.
Team captain Brian O'Driscoll and winger Tommy Bowe scored tries while in a never-to-be-forgotten finish, out-half Ronan O'Gara landed a match-winning drop goal and a last-gasp penalty effort from Wales' Stephen Jones fell short of the posts.
We will have live text commentary direct from Croke Park of Ireland's fourth match of the 2010 Championship, with the hosts fielding an unchanged team and O'Driscoll hoping to mark his 100th Irish cap with a win.
Plug in the laptop or turn on the PC and enjoy a flavour of this afternoon's game live on IrishRugby.ie with thanks to O2, sponsors of MatchDay Live.
There will be full live text and score updates throughout the coverage as Ireland look to chalk up their fourteenth Test win in 17 matches under Declan Kidney.
We provide links to the audio match commentary from the RTE Radio 1, BBC Radio Ulster and BBC 5Live teams.
Starting at 2pm with our pre-match build-up (the game kicks off at 2.30pm), you can feel part of the action on IrishRugby.ie with MatchDay Live.
The match is also being broadcast live on RTE Two and BBC One.
Look out for the MatchDay Live button in the RBS 6 Nations and Ireland sections, or simply click on the link below:
O2 MatchDay Live - Click Here