The Dragons will be anxious to secure the victory to continue their push for a coveted top four spot and maintain their challenge for a play-off place come the end of the regular season.
Thursday sees two further games in Ireland - Leinster host Glasgow Warriors and Munster face the Scarlets.
Just one match point separates top of the table Leinster and the fourth-placed Warriors, although Leinster do have a game in hand over their opponents.
The Warriors have a poor away record in Dublin, whilst Leinster have not lost at the RDS since September 2008.
The final game pits reigning Magners League champions Munster against the 2003/04 champions, the Scarlets.
Just outside the play-off zone, three points adrift of Glasgow, Munster need the victory to keep in touch with the top four.
The Welsh region has won only once before on Munster soil, in September 2003, so have a tough task ahead of them.
MAGNERS LEAGUE - REARRANGED ROUND 11 FIXTURES:
Wednesday, March 17 -
CONNACHT v Newport Gwent Dragons, the Sportsground, 6.30pm
Thursday, March 18 -
LEINSTER v Glasgow Warriors, the RDS, 7.30pm
MUNSTER v Scarlets, Musgrave Park, 7.35pm (live Setanta Sports 1/S4C)